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Effect of Statins on Skeletal Muscle Function
| Content Provider | Scilit |
|---|---|
| Author | Parker, Beth A. Capizzi, Jeffrey A. Grimaldi, Adam S. Clarkson, Priscilla M. Cole, Stephanie M. Keadle, Justin Chipkin, Stuart Pescatello, Linda S. Simpson, Kathleen White, C. Michael Thompson, Paul D. |
| Copyright Year | 2013 |
| Description | Journal: Circulation Background—: Many clinicians believe that statins cause muscle pain, but this has not been observed in clinical trials, and the effect of statins on muscle performance has not been carefully studied. Methods and Results—: The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study assessed symptoms and measured creatine kinase, exercise capacity, and muscle strength before and after atorvastatin 80 mg or placebo was administered for 6 months to 420 healthy, statin-naive subjects. No individual creatine kinase value exceeded 10 times normal, but average creatine kinase increased 20.8±141.1 U/L ( P <0.0001) with atorvastatin. There were no significant changes in several measures of muscle strength or exercise capacity with atorvastatin, but more atorvastatin than placebo subjects developed myalgia (19 versus 10; P =0.05). Myalgic subjects on atorvastatin or placebo had decreased muscle strength in 5 of 14 and 4 of 14 variables, respectively ( P =0.69). Conclusions—: These results indicate that high-dose atorvastatin for 6 months does not decrease average muscle strength or exercise performance in healthy, previously untreated subjects. Nevertheless, this blinded, controlled trial confirms the undocumented impression that statins increase muscle complaints. Atorvastatin also increased average creatine kinase, suggesting that statins produce mild muscle injury even among asymptomatic subjects. This increase in creatine kinase should prompt studies examining the effects of more prolonged, high-dose statin treatment on muscular performance. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00609063. |
| Related Links | https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.112.136101 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450764/pdf https://www.ahajournals.org/doi/reader/10.1161/CIRCULATIONAHA.112.136101 |
| ISSN | 00097322 |
| e-ISSN | 15244539 |
| DOI | 10.1161/circulationaha.112.136101 |
| Journal | Circulation |
| Issue Number | 1 |
| Volume Number | 127 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Circulation Peripheral Vascular Disease Hydroxymethylglutaryl-coa Reductase Inhibitors |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Cardiology and Cardiovascular Medicine |
