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Repetitive Transcranial Magnetic Stimulation for Mal de Debarquement Syndrome
| Content Provider | Scilit |
|---|---|
| Author | Cha, Yoon-Hee Cui, Yongyan Baloh, Robert W. |
| Copyright Year | 2013 |
| Description | Journal: Otology & Neurotology Objective Mal de debarquement syndrome (MdDS) is a chronic disorder of imbalance characterized by a feeling of rocking and swaying. The disorder starts after prolonged exposure to passive motion such as from a boat or plane. All medical treatment is palliative and symptoms that persist beyond 6 months show low likelihood of remission. This pilot study explored the feasibility and tolerability of repetitive transcranial magnetic stimulation (rTMS) as potential treatment for MdDS. Patients/Intervention Ten subjects (8 women) with persistent MdDS lasting from 10 to 91 months were given 1 session each of 4 counterbalanced protocols: left 10 Hz (high frequency), left 1 Hz (low frequency), right 10 Hz, and right 1 Hz rTMS over the dorsolateral prefrontal cortex (DLPFC). Main Outcome Measure Reduction of rocking sensation reported on a visual analogue scale. Results 1) Right-handers improved most with 10-Hz stimulation over the left DLPFC while left-handers improved most with 10 Hz stimulation over the right DLPFC; 2) low-frequency DLPFC stimulation was associated with symptom worsening in some subjects; 3) duration of symptoms was negatively correlated with treatment response; 4) rTMS was well tolerated in MdDS subjects, showing similar rates of headache (10 of 40 sessions) as for other studies; and 5) fatigue occurred after 6 sessions usually with low-frequency stimulation. Conclusion rTMS was well tolerated in subjects with MdDS with promising short-term symptom improvement. Future studies of rTMS in MdDS may consider sequential days of stimulation, longer post-rTMS observation periods, formal measurement of post-TMS fatigue, and randomization with a sham condition. |
| Related Links | http://europepmc.org/articles/pmc3529198?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529198/pdf |
| Ending Page | 179 |
| Page Count | 5 |
| Starting Page | 175 |
| ISSN | 15317129 |
| e-ISSN | 15374505 |
| DOI | 10.1097/mao.0b013e318278bf7c |
| Journal | Otology & Neurotology |
| Issue Number | 1 |
| Volume Number | 34 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Otology & Neurotology Dorsolateral Prefrontal Cortex, Mal De Debarquement Syndrome, Neuromodulation, Repetitive Transcranial Magnetic Stimulation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology Sensory Systems Neurology (clinical) |
