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Evaluation of Risk for Late Language Emergence After In Utero Antiretroviral Drug Exposure in HIV-exposed Uninfected Infants
| Content Provider | Scilit |
|---|---|
| Author | Rice, Mabel L. Zeldow, Bret Siberry, George K. Purswani, Murli Malee, Kathleen Hoffman, Howard Frederick, Toni Buchanan, Ashley Sirois, Patricia A. Allison, Susannah M. Williams, Paige L. |
| Copyright Year | 2013 |
| Description | Journal: The Pediatric infectious disease journal Background: Combination antiretroviral (cARV) regimens are recommended for pregnant women with HIV to prevent perinatal HIV transmission. Safety is a concern for infants who were HIV-exposed but uninfected, particularly for neurodevelopmental problems, such as language delays. Methods: We studied late language emergence (LLE) in HIV-exposed but uninfected children enrolled in a US-based prospective cohort study. LLE was defined as a caregiver-reported score ≤10th percentile in any of 4 domains of the MacArthur-Bates Communicative Development Inventory for 1-year olds and as ≥1 standard deviation below age-specific norms for the Ages and Stages Questionnaire for 2-year olds. Logistic regression models were used to evaluate associations of in utero cARV exposure with LLE, adjusting for infant, maternal and environmental characteristics. Results: 1129 language assessments were conducted among 792 1- and 2-year-old children (50% male, 62% black and 37% Hispanic). Overall, 86% had in utero exposure to cARV and 83% to protease inhibitors. LLE was identified in 26% of 1-year olds and 23% of 2-year olds, with higher rates among boys. In adjusted models, LLE was not associated with maternal cARV or ARV drug classes in either age group. Among cARV-exposed 1-year olds, increased odds of LLE was observed for those exposed to atazanavir (adjusted odds ratio = 1.83, 95% confidence interval: 1.10–3.04), particularly after the first trimester (adjusted odds ratio = 3.56, P = 0.001), compared with atazanavir-unexposed infants. No associations of individual ARV drugs with LLE were observed among 2-year olds. Conclusions: In utero cARV exposure showed little association with LLE, except for a higher risk of language delay observed in 1-year-old infants with atazanavir exposure. |
| Related Links | http://europepmc.org/articles/pmc3785009?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785009/pdf |
| Ending Page | e413 |
| Page Count | 8 |
| Starting Page | e406 |
| ISSN | 08913668 |
| e-ISSN | 15320987 |
| DOI | 10.1097/inf.0b013e31829b80ee |
| Journal | The Pediatric infectious disease journal |
| Issue Number | 10 |
| Volume Number | 32 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Pediatric infectious disease journal Womens Studies Pregnancy, Hiv-exposed Infants, Antiretroviral, Cohort Study, Language Delay |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pediatrics, Perinatology and Child Health Microbiology (medical) |
