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Tolerogenic Dendritic Cell-Regulatory T-cell Interaction and the Promotion of Transplant Tolerance
| Content Provider | Scilit |
|---|---|
| Author | Thomson, Angus W. Turnquist, Hēth R. Zahorchak, Alan F. Raimondi, Giorgio |
| Copyright Year | 2009 |
| Description | Journal: Transplantation Evidence has accumulated that targeting of donor alloantigen to quiescent dendritic cells (DC) in situ or adoptive DC therapy is associated with the expansion or induction of regulatory T cells (Treg) in experimental organ transplantation. These Treg can mediate suppression of antidonor T-effector cell responses and promote allograft tolerance. In addition, Treg can exert reciprocal, inhibitory effects on DC that maintain their tolerogenic properties. Several groups have exploited DC to expand allo-Ag-specific Treg in vitro, followed by adoptive transfer of the Treg to graft recipients, an approach that holds promise for tolerogenic cell therapy in clinical cell and organ transplantation. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746709/pdf |
| Ending Page | S90 |
| Page Count | 5 |
| Starting Page | S86 |
| ISSN | 00411337 |
| e-ISSN | 15346080 |
| DOI | 10.1097/tp.0b013e3181a2dcec |
| Journal | Transplantation |
| Issue Number | 9 |
| Volume Number | 87 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2009-05-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Transplantation Dendritic Cells, Regulatory T Cells, Transplantation, Tolerance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation |
