Loading...
Please wait, while we are loading the content...
Change in mean transit time, apparent diffusion coefficient, and cerebral blood volume during pediatric diabetic ketoacidosis treatment*
| Content Provider | Scilit |
|---|---|
| Author | Vavilala, Monica S. Marro, Ken I. Richards, Todd L. Roberts, Joan S. Curry, Parichat Pihoker, Catherine Bradford, Heidi Shaw, Dennis |
| Copyright Year | 2011 |
| Description | Journal: Pediatric Critical Care Medicine Objectives: Cerebral edema is a devastating complication of pediatric diabetic ketoacidosis. We examined measures describing potential causes of whole brain and regional brain edema (mean transit time, apparent diffusion coefficient, and relative cerebral blood volume) during treatment of diabetic ketoacidosis in children. Design: Prospective observational study. Setting: Regional children's hospital. Interventions: None. Measurements and Main Results: After Institutional Review Board approval, children admitted with diabetic ketoacidosis (pH <7.3, HCO3 300 mg/dL, and ketosis) underwent two serial paired contrast-enhanced (gadolinium) and diffusion magnetic resonance imaging scans. Change in whole brain and regional (frontal lobe, occipital lobe, and basal ganglia) mean transit time, apparent diffusion coefficient, and relative cerebral blood volume between the two time periods (12–24 hrs) and (36–72 hrs) after start of insulin treatment (time 0) were determined. Thirteen children (median age, 10.3 ± 1.1 yrs; 7 female) with diabetic ketoacidosis were examined. Overall, whole brain and regional mean transit time decreased from time 1 (first magnetic resonance imaging after time 0) to time 2 (second magnetic resonance imaging after time 0) by 51% ± 59% (p = .01), without differences between the brain regions examined. Whole brain apparent diffusion coefficient increased by 4.7% ± 3.4% (p = .001), without differences between the brain regions examined. There was no change in relative cerebral blood volume for the whole brain and for the three brain regions examined. Conclusions: In this study, whole brain mean transit time decreased and apparent diffusion coefficient increased, suggesting a vasogenic process between the two study periods during diabetic ketoacidosis treatment. |
| Related Links | http://europepmc.org/articles/pmc3157541?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157541/pdf |
| Ending Page | e349 |
| Page Count | 6 |
| Starting Page | e344 |
| ISSN | 15297535 |
| DOI | 10.1097/pcc.0b013e3182196c9c |
| Journal | Pediatric Critical Care Medicine |
| Issue Number | 6 |
| Volume Number | 12 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Pediatric Critical Care Medicine Pediatrics and Child Health Apparent Diffusion Coefficient Cerebral Blood Volume Diabetic Ketoacidosis Mean Transit Time |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Pediatrics, Perinatology and Child Health |
