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Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome*
| Content Provider | Scilit |
|---|---|
| Author | Gong, Michelle N. Zhou, Wei Williams, Paige L. Thompson, Taylor B. Pothier, Lucille Christiani, David C. |
| Copyright Year | 2007 |
| Description | Journal: Critical Care Medicine Objective: The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associated with MBL deficiency and increased susceptibility to sepsis. We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS). Design: Nested case-control study. Setting: Tertiary academic medical center. Patients: Two hundred and twelve Caucasians with ARDS and 442 controls genotyped for the variant X, D, B, and C alleles of codon −221, 52, 54, and 57, respectively. Interventions: None. Measurements and Main Results: Patients homozygous for the variant codon 54B allele (54BB) had worse severity of illness on admission (p = .007), greater likelihood of septic shock (p = .04), and increased odds of ARDS (adjusted odds ratio, 6.7; 95% confidence interval, 1.5–31) when compared with heterozygotes and homozygotes for the wild-type allele. This association with ARDS was especially strong among the 311 patients with septic shock (adjusted odds ratio, 12.0; 95% confidence interval, 1.9–74). Among the patients with ARDS, the 54BB genotype was associated with more daily organ dysfunction (p = .01) and higher mortality (adjusted hazard rate, 4.0; 95% confidence interval, 1.6–10). Development of ARDS and outcomes in ARDS did not vary significantly with variant alleles of codon −221, 52, and 57, but the power to detect an effect was limited secondary to the low allele frequencies. Conclusions: The MBL-2 codon 54BB genotype may be important in ARDS susceptibility and outcome. Additional studies are needed to confirm these findings in other populations. |
| Related Links | http://europepmc.org/articles/pmc3090269?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090269/pdf |
| Ending Page | 56 |
| Page Count | 9 |
| Starting Page | 48 |
| ISSN | 00903493 |
| e-ISSN | 15300293 |
| DOI | 10.1097/01.ccm.0000251132.10689.f3 |
| Journal | Critical Care Medicine |
| Issue Number | 1 |
| Volume Number | 35 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2007-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Critical Care Medicine Critical Care Medicine Acute Respiratory Failure Genetic Susceptibility Acute Lung Injury Molecular Epidemiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine |
