NDLI: Neurodevelopmental Outcomes in Children With Congenital Heart Disease

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Neurodevelopmental Outcomes in Children With Congenital Heart Disease—What Can We Impact?

Content Provider	Scilit
Author	Wernovsky, Gil Licht, Daniel J.
Copyright Year	2016
Description	Journal: Pediatric Critical Care Medicine Objectives: The objectives of this review are to discuss the scope of neurologic injuries in newborns with congenital heart disease, the mechanisms of injury, including prenatal, pre-, intra-, and postoperative factors, neurodevelopmental outcomes, and therapeutic strategies for the timely intervention and prevention of neurologic injury. Data Source: MEDLINE and PubMed. Conclusion: At the current time, important research is underway to 1) better understand the developing brain in the fetus with complex congenital heart disease, 2) to identify modifiable risk factors in the operating room and ICU to maximize long-term neurodevelopmental outcomes, and 3) develop strategies to improve family psychosocial health, childhood development, and health-related quality of life following hospital discharge. Crucial in this effort is the identification of an early postoperative surrogate variable with good predictive validity for long-term outcomes. If an appropriate surrogate variable for long-term outcomes can be identified, and measured relatively early after surgical intervention for complex congenital heart disease, reliable clinical trials can be undertaken to improve upon current outcomes.
Related Links	http://europepmc.org/articles/pmc4975480?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975480/pdf
Ending Page	S242
Page Count	11
Starting Page	S232
ISSN	15297535
DOI	10.1097/pcc.0000000000000800
Journal	Pediatric Critical Care Medicine
Volume Number	17
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2016-08-01
Access Restriction	Open
Subject Keyword	Journal: Pediatric Critical Care Medicine Pediatrics and Child Health Cardiac Surgery Cardiopulmonary Bypass Neurologic Injury
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine Pediatrics, Perinatology and Child Health

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