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Survival of HIV-1 vertically infected children
| Content Provider | Scilit |
|---|---|
| Author | Davies, Mary-Ann Gibb, Diana Turkova, Anna |
| Copyright Year | 2016 |
| Description | Journal: Current Opinion in HIV and AIDS Purpose of review It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. Recent findings Good survival has been achieved on cART in all settings with up to 10-fold mortality reductions compared with before cART availability. Although mortality risk remains high in the first few months after cART initiation in young children with severe disease, it drops rapidly thereafter even for those who started with advanced disease, and longer term mortality risk is low. However, suboptimal retention on cART in routine programs threatens good survival outcomes and even on treatment children continue to experience high comorbidity risk; infections remain the major cause of death. Interventions to address infection risk include a cotrimoxazole prophylaxis, isoniazid preventive therapy, routine childhood and influenza immunization, and improving maternal survival. Summary Pediatric survival has improved substantially with cART and HIV-infected children are aging into adulthood. It is important to ensure access to diagnosis and early cART, good program retention as well as optimal comorbidity prophylaxis and treatment to achieve the best possible long-term survival and health outcomes for vertically infected children. |
| Related Links | http://europepmc.org/articles/pmc5384722?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384722/pdf |
| Ending Page | 464 |
| Page Count | 10 |
| Starting Page | 455 |
| ISSN | 1746630X |
| e-ISSN | 17466318 |
| DOI | 10.1097/coh.0000000000000303 |
| Journal | Current Opinion in HIV and AIDS |
| Issue Number | 5 |
| Volume Number | 11 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2016-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current Opinion in HIV and AIDS Combination Antiretroviral Therapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology Hematology Immunology Oncology (nursing) Oncology |
