NDLI: Mitogen-Activated Protein Kinases in Heart Development and Diseases

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Mitogen-Activated Protein Kinases in Heart Development and Diseases

Content Provider	Scilit
Author	Wang, Yibin
Copyright Year	2007
Description	Journal: Circulation Mitogen-activated protein (MAP) kinases belong to a highly conserved family of Ser-Thr protein kinases in the human kinome and have diverse roles in broad physiological functions. The 4 best-characterized MAP kinase pathways, ERK1/2, JNK, p38, and ERK5, have been implicated in different aspects of cardiac regulation, from development to pathological remodeling. Recent advancements in the development of kinase-specific inhibitors and genetically engineered animal models have revealed significant new insights about MAP kinase pathways in the heart. However, this explosive body of new information also has yielded many controversies about the functional role of specific MAP kinases as either detrimental promoters or critical protectors of the heart during cardiac pathological processes. These uncertainties have raised questions on whether/how MAP kinases can be targeted to develop effective therapies against heart diseases. In this review, recent studies examining the role of MAP kinase subfamilies in cardiac development, hypertrophy, and survival are summarized.
Related Links	https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.106.679589 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808829/pdf
Ending Page	1423
Page Count	11
Starting Page	1413
ISSN	00097322
e-ISSN	15244539
DOI	10.1161/circulationaha.106.679589
Journal	Circulation
Issue Number	12
Volume Number	116
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2007-09-18
Access Restriction	Open
Subject Keyword	Journal: Circulation Heart Failure Molecular Biology Signal Transduction
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Cardiology and Cardiovascular Medicine

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