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Endometriosis and Risk of Coronary Heart Disease
| Content Provider | Scilit |
|---|---|
| Author | Mu, Fan Rich-Edwards, Janet Rimm, Eric B. Spiegelman, Donna Missmer, Stacey A. |
| Copyright Year | 2016 |
| Description | Journal: Circulation: Cardiovascular Quality and Outcomes Background—: Endometriosis is a prevalent gynecologic disease associated with systemic chronic inflammation, heightened oxidative stress, and atherogenic lipid profile that may increase women’s risk for coronary heart disease (CHD). Methods and Results—: We examined the prospective association between laparoscopically confirmed endometriosis and subsequent CHD among 116 430 women in the Nurses’ Health Study II (1989–2009). Participants with a history of heart disease and stroke were excluded. When compared with women without endometriosis, women with laparoscopically confirmed endometriosis had a higher risk of myocardial infarction (relative risk, 1.52; 95% confidence interval, 1.17–1.98), angiographically confirmed angina (1.91; 1.59–2.29), coronary artery bypass graft surgery/coronary angioplasty procedure/stent (1.35; 1.08–1.69), or any of these CHD end points combined (1.62; 1.39–1.89), independent of potential demographic, anthropometric, family history, reproductive, and lifestyle confounders. Relative risk for the combined CHD end point was highest among women aged ≤40 years (3.08; 2.02–4.70) and decreased as age increased (40< age ≤50 years, 1.65; 1.35–2.02; 50< age ≤55 years, 1.44; 1.07–1.94; and age >55 years, 0.98; 0.56–1.72; P value, test for heterogeneity=0.001). Having had a hysterectomy/oophorectomy was associated with higher risk of combined CHD compared with not having had a hysterectomy/oophorectomy (1.51; 1.34–1.71). A percentage of 42 of the association between endometriosis and CHD could be explained by greater frequency of hysterectomy/oophorectomy and earlier age at surgery after endometriosis diagnosis. Conclusions—: In this large, prospective cohort, laparoscopically confirmed endometriosis was associated with increased risk of CHD. The association was strongest among young women. Hysterectomy/oophorectomy was associated with higher risk of CHD and could partially explain the association between endometriosis and CHD. |
| Related Links | http://europepmc.org/articles/pmc4940126?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940126/pdf https://www.ahajournals.org/doi/pdf/10.1161/CIRCOUTCOMES.115.002224 |
| Ending Page | 264 |
| Page Count | 8 |
| Starting Page | 257 |
| ISSN | 19417713 |
| e-ISSN | 19417705 |
| DOI | 10.1161/circoutcomes.115.002224 |
| Journal | Circulation: Cardiovascular Quality and Outcomes |
| Issue Number | 3 |
| Volume Number | 9 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2016-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Circulation: Cardiovascular Quality and Outcomes Peripheral Vascular Disease Coronary Artery Disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
