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Neurodevelopmental Outcomes in Preschool and School Aged Children With Biliary Atresia and Their Native Liver
| Content Provider | Scilit |
|---|---|
| Author | Squires, James E. Ng, Vicky Lee Hawthorne, Kieran Henn, Lisa L. Sorensen, Lisa G. Fredericks, Emily M. Alonso, Estella M. Murray, Karen F. Loomes, Kathleen M. Karpen, Saul J. Cavallo, Laurel A. Molleston, Jean P. Bezerra, Jorge A. Rosenthal, Philip Squires, Robert H. Wang, Kasper S. Schwarz, Kathleen B. Arnon, Ronen Magee, John C. Sokol, Ronald J. |
| Copyright Year | 2020 |
| Description | Journal: Journal of pediatric gastroenterology and nutrition Objectives: The aim of the study was to assess neurodevelopmental outcomes among children with biliary atresia (BA) surviving with their native liver at ages 3 to 12 years and evaluate variables that associate with neurodevelopment. Methods: Participants (ages 3–12 years) in a prospective, longitudinal, multicenter study underwent neurodevelopmental testing with Weschler Preschool and Primary Scale of Intelligence, 3rd edition (WPPSI-III, ages 3–5 years) and Weschler Intelligence Scale for Children, 4th edition (WISC-IV, ages 6–12 years). Continuous scores were analyzed using Kolmogorov-Smironov tests compared with a normal distribution (mean = 100 ± 15). Effect of covariates on Full-Scale Intelligence Quotient (FSIQ) was analyzed using linear regression. Results: Ninety-three participants completed 164 WPPSI-III (mean age 3.9) and 51 WISC-IV (mean age 6.9) tests. WPPSI-III FSIQ (104 ± 14, P < 0.02), Verbal IQ (106 ± 14, P < 0.001), and General Language Composite (107 ± 16, P < 0.001) distributions were shifted higher compared with test norms. WISC-IV FSIQ (105 ± 12, P < 0.01), Perceptual Reasoning Index (107 ± 12, P < 0.01), and Processing Speed Index (105 ± 10, P < 0.02) also shifted upwards. In univariate and multivariable analysis, parent education (P < 0.01) was a significant predictor of FSIQ on WPPSI-III and positively associated with WISC-IV FSIQ. Male sex and higher total bilirubin and gamma glutamyl transferase (GGT) predicted lower WPPSI-III FSIQ. Portal hypertension was predictive of lower WISC-IV FSIQ. Conclusions: This cohort of children with BA and native liver did not demonstrate higher prevalence of neurodevelopmental delays. Markers of advanced liver disease (higher total bilirubin and GGT for age ≤5 years; portal hypertension for age ≥6) correlate with lower FSIQ and may identify a vulnerable subset of patients who would benefit from intervention. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934908/pdf |
| Ending Page | 86 |
| Page Count | 8 |
| Starting Page | 79 |
| ISSN | 02772116 |
| e-ISSN | 15364801 |
| DOI | 10.1097/mpg.0000000000002489 |
| Journal | Journal of pediatric gastroenterology and nutrition |
| Issue Number | 1 |
| Volume Number | 70 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2020-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of pediatric gastroenterology and nutrition Pediatrics and Child Health Chronic Liver Disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology Pediatrics, Perinatology and Child Health |
