CD4 T-cell regeneration in HIV-1 elite controllers

Content Provider	Scilit
Author	Yang, Yue Al-Mozaini, Maha Buzon, Maria Jose Beamon, Jill Ferrando-Martinez, Sara Ruiz-Mateos, Ezequiel Rosenberg, Eric S. Pereyra, Florencia Yu, Xu G. Lichterfeld, Mathias
Copyright Year	2012
Description	Journal: Aids Background: Elite controllers spontaneously control HIV-1 replication, which in many cases is associated with preservation of normal CD4 T-cell counts. However, a subset of elite controllers has progressive CD4 T-cell losses despite undetectable viral loads, for reasons that remain undefined. Here, we assessed mechanisms of CD4 T-cell homeostasis in elite controllers with progressive vs. nonprogressive HIV-1 disease courses. Methods: Flow cytometry assays were used to determine the proliferation, activation and apoptosis levels of naive T cells in elite controllers with high or low CD4 T-cell counts and reference cohorts of HIV-1-negative and HAART-treated persons. Thymic output was measured by single-joint T-cell receptor excision circle (sjTREC)/β T-cell receptor excision circle (βTREC) ratios, and the frequency of circulating recent thymic emigrants was flow cytometrically determined by surface expression of protein tyrosine kinase 7. Results: Proportions of naive T cells in elite controllers were severely reduced and closely resemble those of HIV-1 patients with progressive disease. Despite reductions in naive T cells, most elite controllers were able to maintain normal total CD4 T-cell counts by preservation of uncompromised thymic function in conjunction with extrathymic processes that led to elevated levels of circulating recent thymic emigrants. In contrast, elite controllers with low CD4 T-cell counts had reduced thymic output that mirrored thymic dysfunction during untreated progressive HIV-1 infection. Conclusion: These results indicate that both thymic and extrathymic mechanisms contribute to CD4 T-cell maintenance in elite controllers and support the idea that CD4 T-cell homeostasis and control of viral replication are distinct but frequently coinciding processes.
Related Links	http://europepmc.org/articles/pmc3729591?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729591/pdf
Ending Page	706
Page Count	6
Starting Page	701
ISSN	02699370
e-ISSN	14735571
DOI	10.1097/qad.0b013e3283519b22
Journal	Aids
Issue Number	6
Volume Number	26
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2012-03-27
Access Restriction	Open
Subject Keyword	Journal: Aids Respiratory System Elite Controllers, Hiv-1, Naive T Cells, Thymic Function
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy Immunology