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Homocysteine-Lowering and Cardiovascular Disease Outcomes in Kidney Transplant Recipients
| Content Provider | Scilit |
|---|---|
| Author | Bostom, Andrew G. Carpenter, Myra A. Kusek, John W. Levey, Andrew S. Hunsicker, Lawrence Pfeffer, Marc A. Selhub, Jacob Jacques, Paul F. Cole, Edward Gravens-Mueller, Lisa Kew, Clifton McKenney, Joyce L. Pacheco-Silva, Alvaro Pesavento, Todd Pirsch, John Smith, Stephen Solomon, Scott Weir, Matthew |
| Copyright Year | 2011 |
| Description | Journal: Circulation Background— Kidney transplant recipients, like other patients with chronic kidney disease, experience excess risk of cardiovascular disease and elevated total homocysteine concentrations. Observational studies of patients with chronic kidney disease suggest increased homocysteine is a risk factor for cardiovascular disease. The impact of lowering total homocysteine levels in kidney transplant recipients is unknown. Methods and Results— In a double-blind controlled trial, we randomized 4110 stable kidney transplant recipients to a multivitamin that included either a high dose (n=2056) or low dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreasing total homocysteine concentrations reduced the rate of the primary composite arteriosclerotic cardiovascular disease outcome (myocardial infarction, stroke, cardiovascular disease death, resuscitated sudden death, coronary artery or renal artery revascularization, lower-extremity arterial disease, carotid endarterectomy or angioplasty, or abdominal aortic aneurysm repair). Mean follow-up was 4.0 years. Treatment with the high-dose multivitamin reduced homocysteine but did not reduce the rates of the primary outcome (n=547 total events; hazards ratio [95 confidence interval]=0.99 [0.84 to 1.17]), secondary outcomes of all-cause mortality (n=431 deaths; 1.04 [0.86 to 1.26]), or dialysis-dependent kidney failure (n=343 events; 1.15 [0.93 to 1.43]) compared to the low-dose multivitamin. Conclusions— Treatment with a high-dose folic acid, B6, and B12 multivitamin in kidney transplant recipients did not reduce a composite cardiovascular disease outcome, all-cause mortality, or dialysis-dependent kidney failure despite significant reduction in homocysteine level. Clinical Trial Registration— http://www.clinicaltrials.gov . Unique identifier: NCT00064753. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887854/pdf |
| Ending Page | 1770 |
| Page Count | 8 |
| Starting Page | 1763 |
| ISSN | 00097322 |
| e-ISSN | 15244539 |
| DOI | 10.1161/circulationaha.110.000588 |
| Journal | Circulation |
| Issue Number | 16 |
| Volume Number | 123 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-04-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: Circulation Urology and Nephrology Cardiovascular Disease Risk Factors Clinical Trials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Cardiology and Cardiovascular Medicine |
