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Apelin/APJ Signaling Is a Critical Regulator of Statin Effects in Vascular Endothelial Cells—Brief Report
| Content Provider | Scilit |
|---|---|
| Author | McLean, Danielle L. Kim, Jongmin Kang, Yujung Shi, Hong Atkins, G. Brandon Jain, Mukesh K. Chun, Hyung J. |
| Copyright Year | 2012 |
| Description | Journal: Arteriosclerosis, thrombosis, and vascular biology Objective— The endothelial response elicited by the G-protein−coupled receptor pathway involving apelin and APJ predicts an overall vasoprotective effect. As a number of downstream endothelial targets of apelin/APJ signaling are also known to be targeted by statins (3-hydroxy-3-methyl-glutaryl [HMG]-CoA reductase inhibitors) as potential mediators of their known pleiotropic effects, we evaluated for the involvement of apelin/APJ signaling in statin endothelial effects. Methods and Results— We found that disruption of apelin/APJ signaling in endothelial cells leads to significantly decreased expression of Krűppel-like factor 2, endothelial nitric oxide synthase, and thrombomodulin. We found that statin-mediated induction of Krűppel-like factor 2, endothelial nitric oxide synthase, and thrombomodulin expression, as well as inhibition of monocyte-endothelial adhesion, was abrogated by concurrent apelin knockdown. Moreover, we found that statins can transcriptionally regulate APJ in a Krűppel-like factor 2−dependent manner, demonstrating the presence of a positive-feedback loop. Conclusion— Our findings provide a novel mechanism by which the apelin/APJ pathway serves as a critical intermediary that links statin to its pleiotropic effects in regulating endothelial gene targets and function. |
| Related Links | https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.112.300317 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495062/pdf https://www.ahajournals.org/doi/reader/10.1161/ATVBAHA.112.300317 |
| Ending Page | 2643 |
| Page Count | 4 |
| Starting Page | 2640 |
| ISSN | 10795642 |
| e-ISSN | 15244636 |
| DOI | 10.1161/atvbaha.112.300317 |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Issue Number | 11 |
| Volume Number | 32 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2012-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Arteriosclerosis, thrombosis, and vascular biology Endocrinology and Metabolism |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
