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Emerging frontiers in pancreatic cancer research
| Content Provider | Scilit |
|---|---|
| Author | Kumar-Sinha, Chandan Wei, Iris Simeone, Diane M. |
| Copyright Year | 2012 |
| Description | Journal: Current opinion in gastroenterology We review recent literature with a view to forge an integrative understanding of the molecular, cellular and extracellular milieu of pancreatic cancer, and discuss them in the context of development of novel, personalized therapeutic options. Pancreatic tumorigenesis, examined using genetically engineered mouse models, appears to be driven by local inflammation, in concert with the 'big four' mutations involving oncogenic KRAS, SMAD4, CDKN2A, and TP53, through induction of epithelial-to-mesenchymal transition (EMT) and cancer stem cells, and accompanied by metastasis. High-throughput sequencing of pancreatic ductal adenocarcinoma as well as neuroendocrine tumors and rarer subtypes of cancers of the pancreas has revealed several novel mutations in genes like PALB2, guanine nucleotide-binding protein, alpha stimulating, death-domain-associated protein, α thalassemia/mental retardation syndrome X linked, switch/sucrose nonfermentable pathway related, and in genes in the ubiquitin-dependent pathways such as USP9X. Therapeutic targeting of the tumor-stroma axis by cytokines and immune response modulators and the role of autophagy in pancreatic cancer are some other salient themes explored in the recent publications. Recent publications shed new light on the mutational landscape of pancreatic cancer and further delineate the distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680108/pdf |
| Ending Page | 522 |
| Page Count | 7 |
| Starting Page | 516 |
| ISSN | 02671379 |
| e-ISSN | 15317056 |
| DOI | 10.1097/mog.0b013e3283567f69 |
| Journal | Current opinion in gastroenterology |
| Issue Number | 5 |
| Volume Number | 28 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2012-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current opinion in gastroenterology Gastroenterology and Hepatology Pancreatic Ductal Adenocarcinoma (pdac) Next Generation Sequencing Cancer Stem Cells Genetically Engineered Mouse Models (gemm) of Pancreatic Cancer Desmoplastic Stroma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
