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White Matter Injury After Subarachnoid Hemorrhage
| Content Provider | Scilit |
|---|---|
| Author | Egashira, Yusuke Zhao, Hao Hua, Ya Keep, Richard F. Xi, Guohua |
| Copyright Year | 2015 |
| Description | Journal: Stroke Background and Purpose—: We recently observed early white matter injury after experimental subarachnoid hemorrhage (SAH), but the underlying mechanisms are uncertain. This study investigated the potential role of matrix metalloproteinase (MMP)-9 in blood–brain barrier (BBB) disruption and consequent white matter injury. Methods—: SAH was induced by endovascular perforation in adult male mice. The following 3 experiments were devised: (1) mice underwent magnetic resonance imaging at 24 h after SAH and were euthanized to determine BBB disruption and MMP-9 activation in white matter; (2) to investigate the role of MMP-9 in BBB disruption, lesion volumes on magnetic resonance imaging were compared between wild-type (WT) and MMP-9 knockout (MMP-9$ ^{−/−}$ ) mice at 24 h after SAH; (3) WT and MMP-9$ ^{−/−}$ mice underwent magnetic resonance imaging at 1 and 8 days after SAH to detect time-dependent changes in brain injury. Brains were used to investigate myelin integrity in white matter. Results—: In WT mice with SAH, white matter showed BBB disruption (albumin leakage) and T2 hyperintensity on magnetic resonance imaging. MMP-9 activity was elevated at 24 h after SAH. MMP-9$ ^{−/−}$ mice had less white matter T2 hyperintensity after SAH than WT mice. At 8 days after SAH, WT mice had decreased myelin integrity and MMP-9$ ^{−/−}$ mice developed less white matter injury. Conclusions—: SAH causes BBB disruption and consequent injury in white matter. MMP-9 plays an important role in those pathologies and could be a therapeutic target for SAH-induced white matter injury. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589516/pdf https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.115.010351 |
| Ending Page | 2915 |
| Page Count | 7 |
| Starting Page | 2909 |
| ISSN | 00392499 |
| e-ISSN | 15244628 |
| DOI | 10.1161/strokeaha.115.010351 |
| Journal | Stroke |
| Issue Number | 10 |
| Volume Number | 46 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2015-10-01 |
| Access Restriction | Open |
| Subject Keyword | Subarachnoid Hemorrhage Blood–brain Barrier Matrix Metalloproteinase-9 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical) |
