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Neutrophils—A Key Component of Ischemia-Reperfusion Injury
| Content Provider | Scilit |
|---|---|
| Author | Schofield, Zoe Victoria Woodruff, Trent Halai, Reena Wu, Mike Chia-Lun Cooper, Matthew |
| Copyright Year | 2013 |
| Description | Journal: Shock Ischemia-reperfusion injury (IRI) is a common occurrence following myocardial infarction, transplantation, stroke, and trauma that can lead to multiple organ failure, which remains the foremost cause of death in critically ill patients. Current therapeutic strategies for IRI are mainly palliative, and there is an urgent requirement for a therapeutic that could prevent or reverse tissue damage caused by IRI. Neutrophils are the primary responders following ischemia and reperfusion and represent important components in the protracted inflammatory response and severity associated with IRI. Experimental studies demonstrate neutrophil infiltration at the site of ischemia and show that inducing neutropenia can protect organs from IRI. In this review, we highlight the mechanisms involved in neutrophil recruitment, activation, and adherence and how this contributes to disease severity in IRI. Inhibiting neutrophil mobilization, tissue recruitment, and ultimately neutrophil-associated activation of local and systemic inflammatory responses may have therapeutic potential in the amelioration of local and remote tissue damage following IRI. |
| Related Links | https://espace.library.uq.edu.au/view/UQ:319067/UQ319067OA.pdf |
| Ending Page | 470 |
| Page Count | 8 |
| Starting Page | 463 |
| ISSN | 15400514 |
| DOI | 10.1097/shk.0000000000000044 |
| Journal | Shock |
| Issue Number | 6 |
| Volume Number | 40 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Shock Ischemia Reperfusion Injury Inflammatory Response Tissue Damage |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Critical Care and Intensive Care Medicine |
