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Bortezomib-induced Epstein–Barr virus and Kaposi sarcoma herpesvirus lytic gene expression
| Content Provider | Scilit |
|---|---|
| Author | Reid, Erin Gourley |
| Copyright Year | 2011 |
| Description | Journal: Current Opinion in Oncology Purpose of review Gamma herpesviruses (GHVs) are responsible for a substantial proportion of virus-associated human cancers, particularly in immunocompromised individuals. Methods that employ lytic activation of viruses latently infecting tumors represent a novel strategy of antineoplastic therapy. Recent findings The proteasome inhibitor, bortezomib, has been shown to be a potent activator of GHV lytic cycle and has demonstrated activity in case reports of GHV-related malignancies. Although initial reports implicated the inhibition of the NF-κB pathway, more recent studies identify alternative pathways responsible for bortezomib-mediated lytic induction of GHVs and activity against the malignancies that harbor them. Summary Further exploration of proteasome inhibition as an oncolytic strategy is warranted and will require clinical/translational trials to determine whether lytic induction of GHVs correlates with clinical response to bortezomib, and, if so, to optimize this oncolytic strategy. |
| Related Links | http://europepmc.org/articles/pmc4175374?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175374/pdf |
| Ending Page | 487 |
| Page Count | 6 |
| Starting Page | 482 |
| ISSN | 10408746 |
| e-ISSN | 1531703X |
| DOI | 10.1097/cco.0b013e3283499c37 |
| Journal | Current Opinion in Oncology |
| Issue Number | 5 |
| Volume Number | 23 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current Opinion in Oncology Bortezomib, Epstein–barr Virus, Gamma Herpesvirus, Human Immunodeficiency Virus, Kaposi Sarcoma Herpesvirus, Oncolytic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
