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Incidence and Predictors of Venous Thromboembolism After Debulking Surgery for Epithelial Ovarian Cancer
| Content Provider | Scilit |
|---|---|
| Author | Mokri, Bahareh Mariani, Andrea Heit, John A. Weaver, Amy L. McGree, Michaela E. Martin, Janice R. Lemens, Maureen A. Cliby, William A. Bakkum-Gamez, Jamie N. |
| Copyright Year | 2013 |
| Description | Journal: International Journal of Gynecologic Cancer Objective: The aim of this study was to determine the incidence and the risk factors of venous thromboembolism (VTE) within 30 days after primary surgery for epithelial ovarian cancer (EOC).Methods: In a historical cohort study, we estimated the postoperative 30-day cumulative incidence of VTE among consecutive Mayo Clinic patients undergoing primary cytoreduction for EOC between January 2, 2003, and December 29, 2008. We tested perioperative patient characteristics and process-of-care variables (defined by the National Surgical Quality Improvement Program, >130 variables) as potential predictors of postoperative VTE using the Cox proportional hazards modeling.Results: Among 569 cases of primary EOC cytoreduction and/or staging and no recent VTE, 35 developed symptomatic VTE within 30 days after surgery (cumulative incidence = 6.5%; 95% confidence interval, 4.4%–8.6%). Within the cohort, 95 (16.7%) received graduated compression stockings (GCSs), 367 (64.5%) had sequential compression devices + GCSs, and 69 (12.1%) had sequential compression devices + GCSs + postoperative heparin, with VTE rates of 1.1%, 7.4%, and 5.8%, respectively (P= 0.07, $χ^{2}$test). The remaining 38 (6.7%) received various other chemical and mechanical prophylaxis regimens. In the multivariate analysis, current or past tobacco smoking, longer hospital stay, and a remote history of VTE significantly increased the risk for postoperative VTE.Conclusions: Venous thromboembolism is a substantial postoperative complication among women with EOC, and the high cumulative rate of VTE within 30 days after primary surgery suggests that a more aggressive strategy is needed for VTE prevention. In addition, because longer hospital stay is independently associated with a higher risk for VTE, methods to decrease length of stay and minimize factors that contribute to prolonged hospitalization are warranted. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307403/pdf |
| Ending Page | 1691 |
| Page Count | 8 |
| Starting Page | 1684 |
| ISSN | 1048891X |
| e-ISSN | 15251438 |
| DOI | 10.1097/igc.0b013e3182a80aa7 |
| Journal | International Journal of Gynecologic Cancer |
| Issue Number | 9 |
| Volume Number | 23 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Gynecologic Cancer Obstetrics and Gynecology Venous Thromboembolism Deep Vein Thrombosis Ovarian Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology Obstetrics and Gynecology |
