NDLI: P2Y$ _{12}$ Receptor Modulates Sepsis-Induced Inflammation

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P2Y$ _{12}$ Receptor Modulates Sepsis-Induced Inflammation

Content Provider	Scilit
Author	Liverani, Elisabetta Rico, Mario C. Tsygankov, Alexander Y. Kilpatrick, Laurie E. Kunapuli, Satya P.
Copyright Year	2016
Description	Journal: Arteriosclerosis, thrombosis, and vascular biology Objective—: Platelets modulate hemostasis and immune responses via interactions with immune cells through secretion of immunemodulators and cell–cell interactions. The P2Y$ _{12}$ receptor mediates ADP-induced aggregation and secretion in platelets. Approach and Results—: Using a mouse model of intra-abdominal sepsis and acute lung injury, we investigated the role of the P2Y$ _{12}$ receptor in neutrophil migration and lung inflammation in P2Y$ _{12}$ null mice and in mice pretreated with the P2Y$ _{12}$ antagonist clopidogrel. Our data show a decrease in circulating white blood cells and a decrease in platelet activation and platelet–leukocyte interactions in treated mice compared with untreated mice. Additionally, lung injury and platelet sequestration were diminished in clopidogrel-treated mice compared with their untreated septic littermates. Similar results were observed in P2Y$ _{12}$ null mice: platelet activation and platelet–leukocyte aggregates were decreased in septic P2Y$ _{12}$ null mice compared with wild-type mice. P2Y$ _{12}$ null mice were refractory to lung injury compared with wild-type mice. Finally, to evaluate P2Y$ _{12}$ -independent effects of clopidogrel, we pretreated P2Y$ _{12}$ null mice. Interestingly, the number of circulating neutrophils was reduced in treated septic P2Y$ _{12}$ null mice, suggesting neutrophils as a target for clopidogrel pleiotropic effects. No difference was observed in P2Y$ _{1}$ null mice during sepsis, indicating that the P2Y$ _{12}$ receptor is responsible for the effects. Conclusions—: P2Y$ _{12}$ null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y$ _{12}$ receptor during sepsis.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850113/pdf https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.116.307401
Ending Page	971
Page Count	11
Starting Page	961
ISSN	10795642
e-ISSN	15244636
DOI	10.1161/atvbaha.116.307401
Journal	Arteriosclerosis, thrombosis, and vascular biology
Issue Number	5
Volume Number	36
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2016-05-01
Access Restriction	Open
Subject Keyword	Journal: Arteriosclerosis, thrombosis, and vascular biology Acute Lung Injury P2y12 Receptor
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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