Late-onset Bloodstream Infections in Hospitalized Term Infants

Content Provider	Scilit
Author	Testoni, Daniela Hayashi, Madoka Cohen-Wolkowiez, Michael Benjamin, Daniel K. Lopes, Renato D. Clark, Reese Smith, P. Brian
Copyright Year	2014
Description	Journal: The Pediatric infectious disease journal Background: The epidemiology and incidence of late-onset blood stream infections (BSIs) in premature infants have been described, but studies describing late-onset BSI in term infants are sparse. We sought to describe the pathogens, incidence, risk factors and mortality of late-onset BSI in hospitalized term infants. Methods: A cohort study was conducted of infants ≥37 weeks gestational age and ≤120 days of age discharged from Pediatrix Medical Group neonatal intensive care units from 1997 to 2010. We examined all cultures obtained from day of life 4–120 and used multivariable regression to assess risk factors for late-onset BSI. Results: We found a total of 206,019 infants cared for between day of life 4 and 120, and the incidence of late-onset BSI was 2.7/1000 admissions. We identified Gram-positive organisms in 64% of the cultures and Gram-negative organisms in 26%. We found a decreased risk of late-onset BSI in infants with the following characteristics: small for gestational age, delivery by Cesarean, antenatal antibiotic use and discharged in the later years of the study. Late-onset BSI increased the risk of death after controlling for confounders [odds ratio 8.43 (95% confidence interval 4.42–16.07)]. Conclusion: Our data highlight the importance of late-onset BSI in hospitalized term infants. We identified Gram-positive organisms as the most common pathogen, and late-onset BSI was an independent risk factor for death.
Related Links	http://europepmc.org/articles/pmc4160433?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160433/pdf
Ending Page	923
Page Count	4
Starting Page	920
ISSN	08913668
e-ISSN	15320987
DOI	10.1097/inf.0000000000000322
Journal	The Pediatric infectious disease journal
Issue Number	9
Volume Number	33
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2014-09-01
Access Restriction	Open
Subject Keyword	Journal: The Pediatric infectious disease journal Pediatrics and Child Health Sepsis, Infant, Term Birth, Infection
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pediatrics, Perinatology and Child Health Microbiology (medical)