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Immunologic, Virologic, and Pharmacologic Characterization of the Female Upper Genital Tract in HIV-Infected Women
| Content Provider | Scilit |
|---|---|
| Author | Rahangdale, Lisa Kashuba, Angela D. M. Nelson, Julie A. E. Cottrell, Mackenzie Sykes, Craig Emerson, Cindi Young, Steven L. Stevens, Trenton Patterson, Kristine B. Cohen, Myron S. |
| Copyright Year | 2015 |
| Description | Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequencies of potential HIV target cells and increased inflammatory molecules. Despite the activated UGT milieu, HIV RNA could not be detected in paired samples of plasma, cervicovaginal or endometrial lavage. As antiretroviral concentrations were ≥3-fold higher in the endometrium than in the lower genital tract, high antiretroviral penetration and/or metabolism may limit viral replication in the UGT. |
| Related Links | http://europepmc.org/articles/pmc4334681?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334681/pdf |
| Ending Page | 424 |
| Page Count | 5 |
| Starting Page | 420 |
| ISSN | 15254135 |
| e-ISSN | 10779450 |
| DOI | 10.1097/qai.0000000000000480 |
| Journal | JAIDS Journal of Acquired Immune Deficiency Syndromes |
| Issue Number | 4 |
| Volume Number | 68 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Infectious Diseases Hiv, Female, Endometrium, Tenofovir, Antiretroviral, Inflammation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology (medical) |
