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Etiology of Childhood Diarrhea After Rotavirus Vaccine Introduction
| Content Provider | Scilit |
|---|---|
| Author | Becker-Dreps, Sylvia Bucardo, Filemon Vilchez, Samuel Zambrana, Luis Enrique Liu, Lan Weber, David J. Peña, Rodolfo Barclay, Leslie Vinjé, Jan Hudgens, Michael G. Nordgren, Johan Svensson, Lennart Morgan, Douglas R. Espinoza, Félix Paniagua, Margarita |
| Copyright Year | 2014 |
| Description | Journal: The Pediatric infectious disease journal Background: Nicaragua was the first developing nation to implement routine immunization with the pentavalent rotavirus vaccine (RV5). In this RV5-immunized population, understanding infectious etiologies of childhood diarrhea is necessary to direct diarrhea treatment and prevention efforts. Methods: We followed a population-based sample of children <5 years in León, Nicaragua for diarrhea episodes through household visits. Information was obtained on RV5 history and sociodemographics. Stool samples collected during diarrhea episodes and among healthy children underwent laboratory analysis for viral, bacterial and parasitic enteropathogens. Detection frequency and incidence of each enteropathogen was calculated. Results: The 826 children in the cohort experienced 677 diarrhea episodes during 607.5 child-years of exposure time (1.1 episodes per child-year). At least 1 enteropathogen was detected among 61.1% of the 337 diarrheal stools collected. The most common enteropathogens among diarrheal stools were: norovirus (20.4%), sapovirus (16.6%), enteropathogenic Escherichia coli (11.3%), Entamoeba histolytica/dispar (8.3%), Giardia lamblia (8.0%) and enterotoxigenic E. coli (7.7%), with rotavirus detected among 5.3% of diarrheal stools. Enteropathogenic Escherichia coli and enterotoxigenic E. coli were frequently detected among stools from healthy children. Among children with diarrhea, norovirus was more commonly detected among younger children (< 2 years) and G. lamblia was more commonly detected among older children (2–4 years). The mean age of rotavirus detection was 34.6 months. Conclusions: In this Central American community after RV5 introduction, rotavirus was not commonly detected among children with diarrhea. Prevention and appropriate management of norovirus and sapovirus should be considered to further reduce the burden of diarrheal disease. |
| Related Links | http://europepmc.org/articles/pmc4216626?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216626/pdf |
| Ending Page | 1163 |
| Page Count | 8 |
| Starting Page | 1156 |
| ISSN | 08913668 |
| e-ISSN | 15320987 |
| DOI | 10.1097/inf.0000000000000427 |
| Journal | The Pediatric infectious disease journal |
| Issue Number | 11 |
| Volume Number | 33 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2014-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Pediatric infectious disease journal Infectious Diseases Childhood, Community, Diarrhea, Nicaragua, Rotavirus Vaccine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pediatrics, Perinatology and Child Health Microbiology (medical) |
