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Skeletal Response to Resistance and Impact Training in Prostate Cancer Survivors
| Content Provider | Scilit |
|---|---|
| Author | Winters-Stone, Kerri M. Dobek, Jessica C. Bennett, Jill A. Maddalozzo, Gianni F. Ryan, Christopher W. Beer, Tomasz M. |
| Copyright Year | 2014 |
| Description | Journal: Medicine & Science In Sports & Exercise Introduction Androgen deprivation therapy (ADT) is associated with significant bone loss and an increase in fracture risk among prostate cancer survivors (PCS). We investigated whether impact + resistance training could stop ADT-related declines in bone mineral density (BMD) among PCS on ADT. Methods We randomized 51 PCS (mean age, 70.2 yr) currently prescribed ADT to participate in 1 yr of impact + resistance training (Prevent Osteoporosis with Impact + Resistance (POWIR)) or in an exercise placebo program of stretching exercise (FLEX). Outcomes were proximal femur (total hip, femoral neck, and greater trochanter) and spine (L1–L4) BMD (g·cm−2) and bone turnover markers (serum osteocalcin (ng·mL−1) and urinary deoxypyrodinoline cross-links (nmol·mmol−1 Cr)). Results Retention in the 1-yr study was 84% and median attendance to supervised classes was 84% in POWIR and 74% in FLEX. No study-related injuries were reported. There were no significant differences between groups for average L1–L4 BMD or for BMD at any hip site. When examining individual vertebrae, POWIR has a significant effect on preservation of BMD (−0.4%) at the L4 vertebrae compared with losses (−3.1%) in FLEX (P = 0.03). Conclusion Impact + resistance training was a safe and acceptable form of exercise for older PCS on ADT. Among our limited sample, POWIR did not appear to have a clinically meaningful effect on hip or spine BMD, but some evidence of skeletal adaptation to resistance + impact training in an androgen-deprived state was apparent. Future studies need to be conducted on a larger sample of patients and should consider modifications to POWIR that could further enhance loading across the spine and at the hip to preserve BMD at these clinically relevant sites. |
| Related Links | http://europepmc.org/articles/pmc4101037?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101037/pdf |
| Ending Page | 1488 |
| Page Count | 7 |
| Starting Page | 1482 |
| ISSN | 01959131 |
| e-ISSN | 15300315 |
| DOI | 10.1249/mss.0000000000000265 |
| Journal | Medicine & Science In Sports & Exercise |
| Issue Number | 8 |
| Volume Number | 46 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2014-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Medicine & Science In Sports & Exercise Urology and Nephrology Physical Activity Androgen Deprivation Therapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science |
