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Long-term Effects of B-type Natriuretic Peptide Infusion After Acute Myocardial Infarction in a Rat Model
| Content Provider | Scilit |
|---|---|
| Author | George, Isaac Xydas, Steve Klotz, Stefan Hay, Ilan Ng, Chuck Chang, Jonathan Xu, Kai Li, Zhihe Protter, Andrew A. Wu, Ed Xuekui Oz, Mehmet C. Wang, Jie |
| Copyright Year | 2010 |
| Description | Journal: Journal of Cardiovascular Pharmacology Introduction: The effects of exogenous B-type natriuretic peptide (BNP) on postmyocardial infarction (MI) are not known. We tested the hypothesis that in vivo infusion of BNP would improve cardiac function and affect left ventricular (LV) remodeling in an experimental model of MI. Methods: MI was induced by coronary ligation in rats and confirmed by echocardiography. 19 rats were randomized to 1 of 3 groups: sham (n = 7), MI + saline (n = 5), MI + BNP (400 ng·kg−1·minute−1) (n = 7). Infusions were delivered for 7 days via venous catheters tunneled to an infusion pump. Rats were followed for 8 weeks. Echocardiography, hemodynamics, histology, and in vivo and ex vivo pressure-volume relationships were examined. Results: LV systolic pressure, LV dP/dtmax, and infarct size improved with BNP treatment versus control MI group (132 ± 4 vs. 110 ± 2 mm Hg, 8097 ± 317 vs. 5816 ± 378 mm Hg/s, 19.3% ± 1.6% vs. 23.3% ± 1.9%, respectively; all P < 0.05). Ex vivo end-diastolic pressure-volume relationship demonstrated reduced diastolic dysfunction after BNP therapy (P < 0.05 vs. control MI). Serum BNP levels confirmed delivery of BNP. Conclusions: We demonstrate beneficial effects on LV function and decreased LV remodeling with BNP infusion in an experimental model of acute MI. |
| Related Links | http://europepmc.org/articles/pmc3085010?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085010/pdf |
| Ending Page | 20 |
| Page Count | 7 |
| Starting Page | 14 |
| ISSN | 01602446 |
| e-ISSN | 15334023 |
| DOI | 10.1097/fjc.0b013e3181c5e743 |
| Journal | Journal of Cardiovascular Pharmacology |
| Issue Number | 1 |
| Volume Number | 55 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Cardiovascular Pharmacology Peripheral Vascular Disease Natriuretic Peptides, Myocardial Infarction, Remodeling |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Cardiology and Cardiovascular Medicine |
