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Roles of short-chain fatty acids in kidney diseases
| Content Provider | Scilit |
|---|---|
| Author | Li, Ling-Zhi Tao, Si-Bei Ma, Liang Fu, Ping |
| Copyright Year | 2019 |
| Description | Journal: Journal of Mechanical Engineering In kidney diseases, uncontrolled blood pressure, inflammation, oxidative stress, imbalanced immunity response and metabolic dysfunction were associated with the progressive deterioration of renal function. Short chain fatty acids (SCFAs), as a group of metabolites fermented by gut microbiota exerted regulatory effects on kidney diseases through their activation of transmembrane G protein-coupled receptors and their inhibition of histone acetylation. In this review article, we updated recent research advances that provided an opportunity to explore our understanding in physiology and function of SCFAs in kidney disease. We performed a comprehensive search in both PubMed and EMBASE using “short chain fatty acids” and “kidney” with no restrictions on publication date. After reading through the title and abstract for early screening, the full text of relevant studies was identified and reviewed to summarize the roles of SCFAs in kidney diseases. Though controversial, growing evidence suggested SCFAs appeared to have a complex but yet poorly understood communications with cellular and molecular processes that affected kidney function and responses to injury. From recent studies, SCFAs influenced multiple aspects of renal physiology including inflammation and immunity, fibrosis, blood pressure and energy metabolism. The roles of intestinal SCFAs in kidney diseases were exciting regions in recent years, however, clinical trials and animal experiments in kidney diseases were still lacked. Thus, more research would be needed to obtain better understanding of SCFAs’ potential effects in kidney diseases. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511413/pdf |
| Ending Page | 1232 |
| Page Count | 5 |
| Starting Page | 1228 |
| ISSN | 05776686 |
| e-ISSN | 25425641 |
| DOI | 10.1097/cm9.0000000000000228 |
| Journal | Journal of Mechanical Engineering |
| Issue Number | 10 |
| Volume Number | 132 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2019-05-20 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Mechanical Engineering Urology and Nephrology Gut Microbiome Short-chain Fatty Acid Kidney Disease Gut-kidney Axis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Mathematics Mechanical Engineering Computer Science Applications |
