Effects of Halothane on Glucose-stimulated Insulin Secretion and Glucose Oxidation in Isolated Rat Pancreatic Islets

Content Provider	Scilit
Author	Gingerich, Ronald Wright, Peter H. Paradise, Raymond R.
Copyright Year	1980
Description	Journal: Anesthesiology Previous studies have shown that halothane inhibits glucose-stimulated insulin secretion. This study was designed to determine whether the mechanism of inhibition involves a reduction in glucose metabolism. The effects of halothane on glucose (16.7 mM)-stimulated insulin secretion and glucose oxidation were studied in isolated rat pancreatic islets. Halothane, 0.11 mM (0.5 MAC), 0.22 mM (1.0 MAC), and 0.33 mM (1.5 MAC), inhibited glucose-stimulated insulin release in a dose-related manner by 5.2 per cent (NS), 21.0 per cent (P < 0.05), and 32.6 per cent (P < 0.01), respectively. At the 0.33 mM (1.5 MAC) concentration, halothane did not significantly inhibit the oxidation of 6-14C-glucose to 14CO2, although higher concentrations of halothane did result in significant inhibition. The data suggest that halothane's inhibitory effect on glucose-stimulated insulin secretion is not due to interference with glucose oxidation.
Related Links	https://pubs.asahq.org/anesthesiology/article-pdf/53/3/219/302072/0000542-198009000-00008.pdf
Ending Page	222
Page Count	4
Starting Page	219
ISSN	00033022
e-ISSN	15281175
DOI	10.1097/00000542-198009000-00008
Journal	Anesthesiology
Issue Number	3
Volume Number	53
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	1980-09-01
Access Restriction	Open
Subject Keyword	Journal: Anesthesiology Endocrinology and Metabolism Glucose Stimulated Insulin Stimulated Insulin Secretion
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine