Loading...
Please wait, while we are loading the content...
Similar Documents
Intercellular Adhesion Molecule-1 G241R Polymorphism Predicts Risk of Incident Ischemic Stroke
| Content Provider | Scilit |
|---|---|
| Author | Volcik, Kelly A. Ballantyne, Christie M. Hoogeveen, Ron Folsom, Aaron R. Boerwinkle, Eric |
| Copyright Year | 2010 |
| Description | Journal: Stroke Background and Purpose— Intercellular adhesion molecule-1 levels are increased in pathological studies of atherosclerosis. We evaluated 13 491 participants from the Atherosclerosis Risk in Communities Study to determine the association of intercellular adhesion molecule-1 G241R and K469E polymorphisms with incident coronary heart disease and ischemic stroke. Methods— Incidences of ischemic stroke (N=517) and coronary heart disease (N=1629) through 2003 were determined by annual telephone calls and hospital and death certificate surveillance. Risk factors were measured at the baseline examination. Cox proportional-hazards models were used to estimate hazard rate ratios. Results— The intercellular adhesion molecule-1 G241 RR genotype was associated with a significantly increased risk of ischemic stroke in both whites (hazard rate ratio=2.18; 95% CI, 1.01 to 4.68; P =0.05) and blacks (hazard rate ratio=7.04; 95% CI, 3.72 to 13.3; P <0.001). Conclusions— The intercellular adhesion molecule-1 241 RR genotype is associated with an increased risk of incident ischemic stroke in both whites and blacks. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036988/pdf https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.109.575563 |
| Ending Page | 1040 |
| Page Count | 3 |
| Starting Page | 1038 |
| ISSN | 00392499 |
| e-ISSN | 15244628 |
| DOI | 10.1161/strokeaha.109.575563 |
| Journal | Stroke |
| Issue Number | 5 |
| Volume Number | 41 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2010-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Stroke Peripheral Vascular Disease Cell Adhesion Molecules Coronary Heart Disease Intercellular Adhesion Molecule-1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical) |
