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Postmenopausal Effects of Resistance Training on Muscle Damage and Mitochondria
| Content Provider | Scilit |
|---|---|
| Author | Manfredi, Thomas G. Monteiro, Michael A. Lamont, Linda S. Singh, Maria F. Foldvari, Mona White, Sebrina Cosmas, Arthur C. Urso, Maria L. |
| Copyright Year | 2013 |
| Description | Journal: Journal of strength and conditioning research Manfredi, TG, Monteiro, MA, Lamont, LS, Singh, MF, Foldvari, M, White, S, Cosmas, AC, and Urso, ML. Postmenopausal effects of resistance training on muscle damage and mitochondria. J Strength Cond Res 27(2): 556–561, 2013—The purpose of this study was to measure the effects of a 12-month progressive resistance training intervention on muscle morphology and strength gains in postmenopausal women. Skeletal muscle biopsies were obtained from the vastus lateralis of 5 independent community-dwelling women (mean age: 75.6 ± 4.28 years; mean height: 163 ± 5.34 cm; mean weight: 72 ± 17.5 kg) before 6 months and 12 months after progressive resistance training. Muscle strength (1 repetition maximum) was measured at the same time points. After 6 months of training, morphological analysis revealed evidence of increased proteolysis and tissue repair, and rudimentary fiber development. The percent of Z-bands with mild Z-band disruption increased from 43.9% at baseline to 66.7% after 6 months of training (p < 0.01). Mitochondrial volume also increased (percent of mitochondria = 0.86% at baseline, 1.19% at 6 months, and 1.04% at 12 months, p < 0.05), and there was a shift to larger sized mitochondria. The training did not result in statistically significant increases in muscle leg strength (p < 0.18). It appears that mild Z-band disruption acts as a precursor for increased protein synthesis and stimulates an increase in mitochondrial mass. Therefore, although a progressive resistance training program in this population did not increase muscle strength, it did demonstrate clinical applications that lend support to the importance of resistance training in older adults. |
| Related Links | https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1045&context=kinesiology_facpubs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560313/pdf |
| Ending Page | 561 |
| Page Count | 6 |
| Starting Page | 556 |
| ISSN | 10648011 |
| e-ISSN | 15334287 |
| DOI | 10.1519/jsc.0b013e318277a1e4 |
| Journal | Journal of strength and conditioning research |
| Issue Number | 2 |
| Volume Number | 27 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of strength and conditioning research Sport Sciences Exercise Training Muscle Adaptation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science |
