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Refractory status epilepticus in children with and without prior epilepsy or status epilepticus
| Content Provider | Scilit |
|---|---|
| Author | Fernández, Iván Sánchez Jackson, Michele C. Abend, Nicholas S. Arya, Ravindra Brenton, James N. Carpenter, Jessica L. Chapman, Kevin E. Gaillard, William D. Gaínza-Lein, Marina Glauser, Tracy A. Goldstein, Joshua L. Goodkin, Howard P. Helseth, Ashley Kapur, Kush McDonough, Tiffani L. Mikati, Mohamad A. Peariso, Katrina Riviello Jr, James Tasker, Robert C. Topjian, Alexis A. Wainwright, Mark S. Wilfong, Angus Williams, Korwyn Loddenkemper, Tobias |
| Copyright Year | 2016 |
| Description | Journal: Neurology Objective: To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE).Methods: This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatric patients (1 month–21 years of age) with rSE.Results: We enrolled 189 participants (53% male) with a median (25th–75th percentile) age of 4.2 (1.3–9.6) years. Eighty-nine (47%) patients had a prior diagnosis of epilepsy. Thirty-four (18%) patients had a history of SE. The time to the first benzodiazepine was similar in participants with and without a diagnosis of epilepsy (15 [5–60] vs 16.5 [5–42.75] minutes,p= 0.858). Patients with a diagnosis of epilepsy received their first non-benzodiazepine (BZD) antiepileptic drug (AED) later (93 [46–190] vs 50.5 [28–116] minutes,p= 0.002) and were less likely to receive at least one continuous infusion (35/89 [39.3%] vs 57/100 [57%],p= 0.03). Compared to patients with no history of SE, patients with a history of SE received their first BZD earlier (8 [3.5–22.3] vs 20 [5–60] minutes,p= 0.0073), although they had a similar time to first non-BZD AED (76.5 [45.3–124] vs 65 [32.5–156] minutes,p= 0.749). Differences were mostly driven by the patients with an out-of-hospital rSE onset.Conclusions: Our study establishes that children with rSE do not receive more timely treatment if they have a prior diagnosis of epilepsy; however, a history of SE is associated with more timely administration of abortive medication. |
| Related Links | http://europepmc.org/articles/pmc5272971?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272971/pdf https://n.neurology.org/content/neurology/88/4/386.full.pdf |
| Ending Page | 394 |
| Page Count | 9 |
| Starting Page | 386 |
| e-ISSN | 1526632X |
| DOI | 10.1212/wnl.0000000000003550 |
| Journal | Neurology |
| Issue Number | 4 |
| Volume Number | 88 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2016-12-23 |
| Access Restriction | Open |
| Subject Keyword | Journal: Neurology Diagnosis of Epilepsy Status Epilepticus |
| Content Type | Text |
| Resource Type | Article |
