NDLI: Preservation HIV-1–Specific IFNγ+ CD4+ T-Cell Responses in Breakthrough Infections After Exposure to Tenofovir Gel in the CAPRISA 004 Microbicide Trial

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Preservation HIV-1–Specific IFNγ+ CD4+ T-Cell Responses in Breakthrough Infections After Exposure to Tenofovir Gel in the CAPRISA 004 Microbicide Trial

Content Provider	Scilit
Author	Mureithi, Marianne W. Poole, Danielle Naranbhai, Vivek Reddy, Shabashini Mkhwanazi, Nompumelelo P. Sibeko, Sengeziwe Werner, Lise Karim, Quarraisha Abdool Karim, Salim Abdool Ndung'U, Thumbi Altfeld, Marcus
Copyright Year	2012
Description	Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes The Centre for the AIDS Program of Research in South Africa 004 trial demonstrated reduction of sexual HIV-1 acquisition in women using a vaginal microbicide containing tenofovir. A better understanding of the consequences of antiretroviral-containing microbicides for immune responses in individuals with intercurrent HIV-1 infection is needed for future trials combining the use of microbicides with HIV-1 vaccines. Investigation of immune responses in women who acquired HIV-1 although using tenofovir gel showed significantly higher (P = 0.01) Gag-specific IFNγ+ CD4+ T-cell responses. The use of tenofovir-containing gel around the time of infection can modulate HIV-1 immunity, and these immunological changes need to be considered in future trials combining vaccines and microbicides.
Related Links	http://europepmc.org/articles/pmc3381429?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381429/pdf
Ending Page	127
Page Count	4
Starting Page	124
ISSN	15254135
e-ISSN	10779450
DOI	10.1097/qai.0b013e31824f53a9
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Issue Number	2
Volume Number	60
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2012-06-01
Access Restriction	Open
Subject Keyword	Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Infectious Diseases Vaginal Microbicide Hiv-1–specific Cd4+ T-cell Help
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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Preservation HIV-1-specific IFNγ+ CD4+ T cell responses in breakthrough infections following exposure to Tenofovir Gel in the CAPRISA 004 microbicide trial

BRIEF REPORT: BASIC AND TRANSLATIONAL SCIENCE Preservation HIV-1–Specific IFNg+ CD4+ T-Cell Responses in Breakthrough Infections After Exposure to Tenofovir Gel in the CAPRISA 004 Microbicide Trial

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Preservation HIV-1–Specific IFNγ+ CD4+ T-Cell Responses in Breakthrough Infections After Exposure to Tenofovir Gel in the CAPRISA 004 Microbicide Trial

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Preservation HIV-1-specific IFNγ+ CD4+ T cell responses in breakthrough infections following exposure to Tenofovir Gel in the CAPRISA 004 microbicide trial

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