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Serum Antibody Response to Five Streptococcus pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non–otitis-prone Children
| Content Provider | Scilit |
|---|---|
| Author | Kaur, Ravinder Casey, Janet R. Pichichero, Michael E. |
| Copyright Year | 2011 |
| Description | Journal: The Pediatric infectious disease journal Background: Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non–otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children. Objective: From a population of 268 children, we sought to compare the serum IgG antibody titers of 5 different Spn proteins (PhtD, LytB, PcpA, PhtE, and Ply) that are vaccine candidates in children with episodic AOM (n = 34), who were otitis prone (n = 35) and who had AOMTF (n = 25) caused by Spn. Methods: Antibody was quantitated by enzyme-linked immunosorbent assay. Results: At their AOM visit, anti-PhtD, -LytB, -PhtE, and -Ply IgG antibody titers in otitis-prone children were significantly lower compared with non–otitis-prone children (P < 0.05) and children with AOMTF (P < 0.05). On comparing acute to convalescent geometric mean IgG antibody titers after AOM against the 5 proteins we found that otitis-prone, AOMTF, and non-otitis-prone children had no significant change in titers (except for PhtE in children with AOMTF), but detailed analysis showed that about one-third of the children in each cohort had a 2-fold rise in antibody to the studied antigens. Although non–otitis-prone children had significant increases (P < 0.001) between 6 and 24 months of age in anti-PhtD, PcpA, PhtE, and Ply IgG antibody titers as a consequence of nasopharyngeal colonization and AOM, otitis-prone children either failed to show rises or the rises were significantly less than the non–otitis-prone children. Conclusion: Otitis-prone and AOMTF children mount less of an IgG serum antibody response as compared with non–otitis-prone children to Spn proteins after AOM and nasopharyngeal colonization. |
| Related Links | http://europepmc.org/articles/pmc3296524?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296524/pdf |
| Ending Page | 650 |
| Page Count | 6 |
| Starting Page | 645 |
| ISSN | 08913668 |
| e-ISSN | 15320987 |
| DOI | 10.1097/inf.0b013e31821c2d8b |
| Journal | The Pediatric infectious disease journal |
| Issue Number | 8 |
| Volume Number | 30 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Pediatric infectious disease journal Nutrition and Dietetics Acute Otitis Media |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pediatrics, Perinatology and Child Health Microbiology (medical) |
