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Heme oxygenase-1 and acute kidney injury
| Content Provider | Scilit |
|---|---|
| Author | Nath, Karl A. |
| Copyright Year | 2014 |
| Description | Journal: Current opinion in nephrology and hypertension Purpose of review Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide. First shown in acute kidney injury (AKI), HO-1 is now recognized as a protectant against diverse insults in assorted tissues. This review summarizes recent contributions to the field of HO-1 and AKI. Recent findings Recent findings elucidate the following: the transcriptional regulation and significance of human HO-1 in AKI; the protective effects of HO-1 in age-dependent and sepsis-related AKI, cardiorenal syndromes, and acute vascular rejection in renal xenografts; the role of heme oxygenase in tubuloglomerular feedback and renal resistance to injury; the basis for cytoprotection by HO-1; the protective properties of ferritin and carbon monoxide; HO-1 and the AKI–chronic kidney disease transition; HO-1 as a biomarker in AKI; the role of HO-1 in mediating the protective effects of specific cytokines, stem cells, and therapeutic agents in AKI; and HO-2 as a protectant in AKI. Summary Recent contributions support, and elucidate the basis for, the induction of HO-1 as a protectant against AKI. Translating such therapeutic potential into a therapeutic reality requires well tolerated and effective modalities for upregulating HO-1 and/or administering its products, which, optimally, should be salutary even when AKI is already established. |
| Related Links | http://europepmc.org/articles/pmc4137976?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137976/pdf |
| Ending Page | 24 |
| Page Count | 8 |
| Starting Page | 17 |
| ISSN | 10624821 |
| e-ISSN | 14736543 |
| DOI | 10.1097/01.mnh.0000437613.88158.d3 |
| Journal | Current opinion in nephrology and hypertension |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current opinion in nephrology and hypertension Urology and Nephrology Acute Kidney Injury Acute Renal Failure |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Nephrology |
