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Hypertension, Microvascular Pathology, and Prognosis After an Acute Myocardial Infarction
| Content Provider | Scilit |
|---|---|
| Author | Carrick, David Haig, Caroline Maznyczka, Annette M. Carberry, Jaclyn Mangion, Kenneth Ahmed, Nadeem May, Vannesa Teng Yue McEntegart, Margaret Petrie, Mark C. Eteiba, Hany Lindsay, Mitchell Hood, Stuart Watkins, Stuart Davie, Andrew Mahrous, Ahmed Mordi, Ify Ford, Ian Radjenovic, Aleksandra Welsh, Paul Sattar, Naveed Wetherall, Kirsty Oldroyd, Keith G. Berry, Colin |
| Copyright Year | 2018 |
| Description | Journal: Hypertension The rationale for our study was to investigate the pathophysiology of microvascular injury in patients with acute ST-segment–elevation myocardial infarction in relation to a history of hypertension. We undertook a cohort study using invasive and noninvasive measures of microvascular injury, cardiac magnetic resonance imaging at 2 days and 6 months, and assessed health outcomes in the longer term. Three hundred twenty-four patients with acute myocardial infarction (mean age, 59 [12] years; blood pressure, 135 [25] / 79 [14] mm Hg; 237 [73%] male, 105 [32%] with antecedent hypertension) were prospectively enrolled during emergency percutaneous coronary intervention. Compared with patients without antecedent hypertension, patients with hypertension were older (63 [12] years versus 57 [11] years; P <0.001) and a lower proportion were cigarette smokers (52 [50%] versus 144 [66%]; P =0.007). Coronary blood flow, microvascular resistance within the culprit artery, infarct pathologies, inflammation (C-reactive protein and interleukin-6) were not associated with hypertension. Compared with patients without antecedent hypertension, patients with hypertension had less improvement in left ventricular ejection fraction at 6 months from baseline (5.3 [8.2]% versus 7.4 [7.6]%; P =0.040). Antecedent hypertension was a multivariable associate of incident myocardial hemorrhage 2-day post-MI (1.81 [0.98–3.34]; P =0.059) and all-cause death or heart failure (n=47 events, n=24 with hypertension; 2.53 [1.28–4.98]; P =0.007) postdischarge (median follow-up 4 years). Severe progressive microvascular injury is implicated in the pathophysiology and prognosis of patients with a history of hypertension and acute myocardial infarction. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT02072850. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080885/pdf |
| Ending Page | 730 |
| Page Count | 11 |
| Starting Page | 720 |
| ISSN | 0194911X |
| e-ISSN | 15244563 |
| DOI | 10.1161/HYPERTENSIONAHA.117.10786 |
| Journal | Hypertension |
| Issue Number | 3 |
| Volume Number | 72 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2018-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hypertension Cardiology and Cardiovascular Diseases Peripheral Vascular Disease Myocardial Infarction Reperfusion Injury |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine |
