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Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas
| Content Provider | Scilit |
|---|---|
| Author | Köbel, Martin Ronnett, Brigitte M. Singh, Naveena Soslow, Robert A. Gilks, C. Blake McCluggage, W. Glenn |
| Copyright Year | 2019 |
| Description | Journal: International Journal of gynecological Pathology P53 immunohistochemistry has evolved into an accurate surrogate reflecting the underlying TP53 mutation status of a tumor, and has utility in the diagnostic workup of endometrial carcinomas. Recent work predominantly carried out in tubo-ovarian high-grade serous carcinoma has revealed 4 main patterns of p53 staining (normal/wild-type, complete absence, overexpression, and cytoplasmic); the latter 3 patterns are variably termed abnormal/aberrant/mutation-type and are strongly predictive of an underlying TP53 mutation. The aim of this review is to provide practical advice to pathologists regarding various aspects of p53 immunohistochemical staining. These include laboratory methods to optimize staining, a description of the different patterns of staining, advice regarding the interpretation, and reporting of p53 staining and practical uses of p53 staining in endometrial carcinoma diagnosis. Illustrations are provided to aid in the interpretational problems. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127005/pdf |
| Ending Page | S131 |
| Page Count | 9 |
| Starting Page | S123 |
| ISSN | 02771691 |
| e-ISSN | 15387151 |
| DOI | 10.1097/pgp.0000000000000488 |
| Journal | International Journal of gynecological Pathology |
| Volume Number | 38 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of gynecological Pathology Endometrial Carcinoma Immunohistochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine Obstetrics and Gynecology |
