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Anesthetic Propofol Enhances Plasma γ-Tocopherol Levels in Patients Undergoing Cardiac Surgery
| Content Provider | Scilit |
|---|---|
| Author | Cavalca, Viviana Colli, Susanna Veglia, Fabrizio Eligini, Sonia Zingaro, Lorenzo Squellerio, Isabella Rondello, Nicola Cighetti, Giuliana Maria Tremoli, Elena Sisillo, Erminio |
| Copyright Year | 2008 |
| Description | Journal: Anesthesiology Background Propofol (2,6-diisopropylphenol) is an anesthetic drug with antioxidant and antiinflammatory properties, documented both in vitro and in experimental models of ischemia-reperfusion injury and septic shock. These properties have been related to the similarity of its chemical structure to that of endogenous tocopherols, which are phenol-containing radical scavengers. This study evaluated the effects of propofol on alpha- and gamma-tocopherol (alpha- and gamma-T) levels and on selected markers of oxidant-antioxidant and inflammatory status in patients undergoing cardiac surgery. Methods Patients were randomly assigned for anesthesia with either propofol (propofol group, n = 22) or sevoflurane (control group, n = 21). Plasma levels of alpha- and gamma-T, individual antioxidant capacity, malondialdehyde, and interleukin 10 were measured before, during, and after anesthesia. In addition, levels of the proinflammatory prostaglandin E2 as a marker of cyclooxygenase-2 activity and those of interleukin 10 were measured in whole blood cultured with bacterial lipopolysaccharide. Results Gamma-T levels increased significantly during surgery in propofol group (P < 0.0001 vs. control group). By contrast, alpha-T similarly decreased in both groups. Malondialdehyde and interleukin 10 increased markedly and individual antioxidant capacity decreased, without differences between groups. Prostaglandin E2 levels measured 24 h after anesthesia induction were significantly lower in the propofol than in the control group. In vitro studies highlighted the different capacity of gamma- and alpha-T to impair prostaglandin E2 synthesis by human monocytes challenged with bacterial lipopolysaccharide. Conclusions The antiinflammatory properties of propofol that may be linked to its effect on gamma-T levels could be relevant in controlling the inflammatory response that accompanies tissue injury during reperfusion. |
| Related Links | http://anesthesiology.pubs.asahq.org/data/journals/jasa/931055/0000542-200806000-00006.pdf http://anesthesiology.pubs.asahq.org/data/Journals/JASA/931055/0000542-200806000-00006.pdf |
| Ending Page | 997 |
| Page Count | 10 |
| Starting Page | 988 |
| ISSN | 00033022 |
| e-ISSN | 15281175 |
| DOI | 10.1097/aln.0b013e318173efb4 |
| Journal | Anesthesiology |
| Issue Number | 6 |
| Volume Number | 108 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2008-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Anesthesiology Patients Undergoing Undergoing Cardiac Bacterial Lipopolysaccharide Antiinflammatory Properties |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
