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Mechanisms of vascular comorbidity in autoimmune diseases

Content Provider	Scilit
Author	Nagy, György Németh, Nóra Buzás, Edit I.
Copyright Year	2018
Description	Journal: Current Opinion in Rheumatology Alarming statistics support the clinical observations that because of cardiovascular comorbidities patients with inflammatory joint disease die significantly earlier despite successful anti-inflammatory therapy. The reason for this earlier death is multifactorial and involves the complex genetic background, classical cardiovascular risk factors and anti-inflammatory therapy. We also point out the importance of several new influencing mechanisms, especially the diverse intercellular communication routes including extracellular vesicles and microRNAs in the development of cardiovascular comorbidities. The aim of this review is to give an updated overview about the known risk factors in the development of cardiovascular comorbidities with the latest insights about their mechanism of action. Furthermore, the impact of newly identified risk factors and their complex interference and synergies will be discussed.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805124/pdf https://insights.ovid.com/Common/SSRPdf/V1/JOURNAL/corhe/04.02/00002281-900000000-99167/root/v/2017-12-19T184610Z/r/application-pdf
Ending Page	206
Page Count	10
Starting Page	197
ISSN	10408711
e-ISSN	15316963
DOI	10.1097/bor.0000000000000483
Journal	Current Opinion in Rheumatology
Issue Number	2
Volume Number	30
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2018-03-01
Access Restriction	Open
Subject Keyword	Journal: Current Opinion in Rheumatology Medical Laboratory Technology Cardiovascular Comorbidities Extracellular Vesicles Psoriatic Arthritis Rheumatoid Arthritis Systemic Lupus Erythematosus
Content Type	Text
Resource Type	Article
Subject	Rheumatology

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