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Angiogenic factors in preeclampsia

Content Provider	Scilit
Author	Goel, Arvind Rana, Sarosh
Copyright Year	2013
Description	Journal: Current opinion in nephrology and hypertension The review summarizes new observations of key roles for circulating angiogenic factors in diagnosing, managing, and treating preeclampsia. Alterations in circulating angiogenic factors (soluble fms-like tyrosine kinase-1 and placental growth factor) in preeclampsia correlate with the diagnosis and adverse outcomes, particularly when the disease presents prematurely (<34 weeks). Measurement of these angiogenic biomarkers further helps differentiate preeclampsia and its complications from other disorders that present with similar clinical profiles. A ratio of soluble fms-like tyrosine kinase-1/placental growth factor greater than 85 appears ideal as the cut-off for both diagnosis and prognosis. There is also evidence that modulating these factors has therapeutic effects, suggesting a future role for angiogenic factors in treatment and prevention of preeclampsia. Circulating angiogenic biomarkers help in diagnostic and prognostic profiling of preeclampsia and may facilitate better management of these patients.
Related Links	http://europepmc.org/articles/pmc3932709?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932709/pdf
Ending Page	650
Page Count	8
Starting Page	643
ISSN	10624821
e-ISSN	14736543
DOI	10.1097/mnh.0b013e328365ad98
Journal	Current opinion in nephrology and hypertension
Issue Number	6
Volume Number	22
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2013-11-01
Access Restriction	Open
Subject Keyword	Journal: Current opinion in nephrology and hypertension Medical Laboratory Technology Angiogenic Factors Placental Growth Factor (pigf) Soluble Fms-like Tyrosine Kinase-1 (sflt1)
Content Type	Text
Resource Type	Article
Subject	Internal Medicine Nephrology

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Circulating Levels of the Antiangiogenic Marker Soluble FMS-Like Tyrosine Kinase 1 Are Elevated in Women With Pregestational Diabetes and Preeclampsia: Angiogenic markers in preeclampsia and preexisting diabetes

Soluble fms-like tyrosine kinase 1 (sflt1), endoglin and placental growth factor (plgf) in preeclampsia among.

Soluble fms-Like Tyrosine Kinase 1 (sFlt1), Endoglin and Placental Growth Factor (PlGF) in Preeclampsia among High Risk Pregnancies

Endothelin as a final common pathway in the pathophysiology of preeclampsia

Predictive value of soluble fms‐like tyrosine kinase‐1 against placental growth factor for preeclampsia in a Chinese pregnant women population

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.

The effect of placental angiogenic and anti-angiogenic factors on pregnancy outcome in patients with early onset preeclampsia

Performance of sFlt-1/PIGF Ratio for the Prediction of Perinatal Outcome in Obese Pre-Eclamptic Women

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Angiogenic factors in preeclampsia

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Circulating Levels of the Antiangiogenic Marker Soluble FMS-Like Tyrosine Kinase 1 Are Elevated in Women With Pregestational Diabetes and Preeclampsia: Angiogenic markers in preeclampsia and preexisting diabetes

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