Residual functional connectivity in the split-brain revealed with resting-state functional MRI

Content Provider	Scilit
Author	Uddin, Lucina Q. Mooshagian, Eric Zaidel, Eran Scheres, Anouk Margulies, Daniel Kelly, Clare Shehzad, Zarrar Adelstein, Jonathan S. Castellanos, Francisco Milham, Michael P.
Copyright Year	2008
Description	Journal: NeuroReport Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
Related Links	http://europepmc.org/articles/pmc3640406?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640406/pdf
Ending Page	709
Page Count	7
Starting Page	703
ISSN	09594965
e-ISSN	1473558X
DOI	10.1097/wnr.0b013e3282fb8203
Journal	NeuroReport
Issue Number	7
Volume Number	19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2008-05-07
Access Restriction	Open
Subject Keyword	Journal: NeuroReport Commissurotomy, Diffusion Tensor Imaging, Interhemispheric Interaction, Laterality, Resting-state Functional Connectivity
Content Type	Text
Resource Type	Article
Subject	Neuroscience