NDLI: Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

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Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

Content Provider	Scilit
Author	Albrecht, Steffen Bogdanovic, Nenad Ghetti, Bernardino Winblad, Bengt Leblanc, Andréa C.
Copyright Year	2009
Description	Journal: Journal of Neuropathology and Experimental Neurology We previously demonstrated the activation of caspase-6 (Casp-6) in the hippocampus and cortex in cases of mild, moderate, severe, and very severe Alzheimer disease (AD). To determine whether Casp-6 is also activated in familial AD, we performed an immunohistochemical analysis of active Casp-6 and Tau cleaved by Casp-6 in temporal cortex and hippocampal tissue sections from cases of familial AD. The cases included 5 carrying the amyloid precursor protein K670N and M671L Swedish mutation, 1 carrying the amyloid precursor protein E693G Arctic mutation, 2 each carrying the Presenilin I M146V, F105L, A431E, V261F, and Y115C mutations, and 1 with the Presenilin II N141I mutation. Active Casp-6 immunoreactivity was found in all cases. Caspase-6 immunoreactivity was observed in neuritic plaques or in some cases cotton-wool plaques, and in neuropil threads and neurofibrillary tangles. These results indicate that Casp-6 is activated in familial forms of AD, as previously observed in sporadic forms. Because sporadic and familial AD cases have similar pathological features, these results support a fundamental role of Casp-6 in the pathophysiology of both familial and sporadic AD.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079356/pdf https://academic.oup.com/jnen/article-pdf/68/12/1282/8133253/68-12-1282.pdf
Ending Page	1293
Page Count	12
Starting Page	1282
ISSN	00223069
e-ISSN	15546578
DOI	10.1097/nen.0b013e3181c1da10
Journal	Journal of Neuropathology and Experimental Neurology
Issue Number	12
Volume Number	68
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2009-12-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Neuropathology and Experimental Neurology Alzheimer Disease Enzyme Activation Immunohistochemistry Amyloid Precursor Protein
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical) Pathology and Forensic Medicine Cellular and Molecular Neuroscience

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