Loading...
Please wait, while we are loading the content...
Similar Documents
Nebulization With γ-Tocopherol Ameliorates Acute Lung Injury After Burn and Smoke Inhalation in the Ovine Model
| Content Provider | Scilit |
|---|---|
| Author | Yamamoto, Yusuke Enkhbaatar, Perenlei Sousse, Linda E. Sakurai, Hiroyuki Rehberg, Sebastian W. Asmussen, Sven Kraft, Edward R. Wright, Charlotte L. Bartha, Eva Cox, Robert A. Hawkins, Hal K. Traber, Lillian D. Traber, Maret Szabo, Csaba Herndon, David N. Traber, Daniel L. |
| Copyright Year | 2012 |
| Description | Journal: Shock We hypothesize that the nebulization of γ-tocopherol (g-T) in the airway of our ovine model of acute respiratory distress syndrome will effectively improve pulmonary function following burn and smoke inhalation after 96 h. Adult ewes (n = 14) were subjected to 40% total body surface area burn and were insufflated with 48 breaths of cotton smoke under deep anesthesia, in a double-blind comparative study. A customized aerosolization device continuously delivered g-T in ethanol with each breath from 3 to 48 h after the injury (g-T group, n = 6), whereas the control group (n = 5) was nebulized with only ethanol. Animals were weaned from the ventilator when possible. All animals were killed after 96 h, with the exception of one untreated animal that was killed after 64 h. Lung g-T concentration significantly increased after g-T nebulization compared with the control group (38.5 ± 16.8 vs. 0.39 ± 0.46 nmol/g, P < 0.01). The PaO2/FIO2 ratio was significantly higher after treatment with g-T compared with the control group (310 ± 152 vs. 150 ± 27.0, P < 0.05). The following clinical parameters were improved with g-T treatment: pulmonary shunt fraction, peak and pause pressures, lung bloodless wet-to-dry weight ratios (2.9 ± 0.87 vs. 4.6 ± 1.4, P < 0.05), and bronchiolar obstruction (2.0% ± 1.1% vs. 4.6% ± 1.7%, P < 0.05). Nebulization of g-T, carried by ethanol, improved pulmonary oxygenation and markedly reduced the time necessary for assisted ventilation in burn- and smoke-injured sheep. Delivery of g-T into the lungs may be a safe, novel, and efficient approach for management of acute lung injury patients who have sustained oxidative damage to the airway. |
| Related Links | http://europepmc.org/articles/pmc3306540?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306540/pdf |
| Ending Page | 414 |
| Page Count | 7 |
| Starting Page | 408 |
| ISSN | 15400514 |
| DOI | 10.1097/shk.0b013e3182459482 |
| Journal | Shock |
| Issue Number | 4 |
| Volume Number | 37 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2012-04-01 |
| Access Restriction | Open |
| Subject Keyword | Obstruction Α-tocopherol Pulmonary Function Early Excision |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Critical Care and Intensive Care Medicine |
