NDLI: Uric acid and hypertension

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Uric acid and hypertension

Content Provider	Scilit
Author	Becker, Benjamin De Borghi, Claudio Burnier, Michel van de Borne, Philippe
Copyright Year	2019
Description	Journal: Journal of Hypertension Uric acid levels are higher in humans than in other mammals. Best known as an extracellular antioxidant, uric acid also increases salt sensitivity, fat storage, and lipogenesis. Xanthine oxidase-related oxidative stress may also induce endothelial dysfunction and renal vasoconstriction. Renal structure abnormalities contribute to salt-sensitive and uric acid-independent hypertension. Maternal hyperuricemia during pregnancy and hyperuricemia early in life are likewise independent risk factors for hypertension. Genetic polymorphism is potentially involved in the activity of xanthine oxidoreductase, but further studies are needed. Xanthine oxidase inhibition consistently decreases blood pressure in younger hypertensive patients, albeit modestly. Hyperuricemia affects one out of five adults as a result of the Western diet, insulin resistance, and renal dysfunction. This review advocates lifestyle changes to maintain uric acid levels within the normal range in young (pre)hypertensive individuals or normotensives with a family history of hypertension, metabolic disorders, or obesity; moreover, antihypertensive medications that increase uric acid levels should be avoided.
Related Links	https://dipot.ulb.ac.be/dspace/bitstream/2013/281922/4/JH-D-18-00515.pdf
Ending Page	883
Page Count	6
Starting Page	878
ISSN	02636352
e-ISSN	14735598
DOI	10.1097/hjh.0000000000001980
Journal	Journal of Hypertension
Issue Number	5
Volume Number	37
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2019-05-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Hypertension Medical Laboratory Technology Xanthine Oxidoreductase
Content Type	Text
Resource Type	Article
Subject	Physiology Internal Medicine Cardiology and Cardiovascular Medicine

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