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Correlation Between Preoperative Serum Concentration of Type IV Collagen 7s Domain and Hepatic Failure Following Resection of Hepatocellular Carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Kubo, Shoji Tsukamoto, Tadashi Hirohashi, Kazuhiro Tanaka, Hiromu Shuto, Taichi Takemura, Shigekazu Yamamoto, Takatsugu Uenishi, Takahiro Ogawa, Masao Kinoshita, Hiroaki |
| Copyright Year | 2004 |
| Description | Journal: Annals of Surgery To determine the predictive value of the preoperative serum concentration of type IV collagen 7s domain (7s collagen) for postoperative hepatic failure in patients undergoing liver resection for hepatocellular carcinoma. Clear and reliable criteria for predicting hepatic failure after liver resection are needed. The serum 7s collagen concentration correlates with the histologic degree of active hepatitis and hepatic fibrosis and may predict the regenerative potential of the liver. Potential risk factors for postoperative hepatic failure, including the serum 7s collagen concentration, were evaluated in 251 patients who underwent liver resection for hepatocellular carcinoma. Prognostic significance was determined by univariate and multivariate analyses. Hepatic failure developed postoperatively in 25 patients, 4 of whom died. The serum 7s collagen concentration correlated with the histologic degree of hepatitis activity and hepatic fibrosis. The serum 7s collagen concentration was a risk factor for postoperative hepatic failure by univariate analysis and was the only risk factor on multivariate analysis. No patient with a serum 7s collagen concentration or=12 ng/mL. The preoperative serum 7s collagen concentration correlated independently with hepatic failure following liver resection for hepatocellular carcinoma. Patients whose serum 7s collagen is >or=12 ng/mL are poor candidates for hepatic resection. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356211/pdf |
| Ending Page | 193 |
| Page Count | 8 |
| Starting Page | 186 |
| ISSN | 00034932 |
| e-ISSN | 15281140 |
| DOI | 10.1097/01.sla.0000109152.48425.4d |
| Journal | Annals of Surgery |
| Issue Number | 2 |
| Volume Number | 239 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2004-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of Surgery 7s Collagen Multivariate Analysis Liver Resection Hepatic Failure After Liver |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery |
