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Sex Differences in Predictors of Longitudinal Changes in Carotid Artery Stiffness
| Content Provider | Scilit |
|---|---|
| Author | Stern, Rebecca Tattersall, Matthew C. Gepner, Adam D. Korcarz, Claudia E. Kaufman, Joel Colangelo, Laura A. Liu, Kiang Stein, James H. |
| Copyright Year | 2015 |
| Description | Journal: Arteriosclerosis, thrombosis, and vascular biology Objective—: To identify sex differences in predictors of longitudinal changes in carotid arterial stiffness in a multiethnic cohort. Approach and Results—: Carotid artery distensibility coefficient (DC) and Young’s elastic modulus (YEM) were measured in 2650 Multi-Ethnic Study of Atherosclerosis participants (45–84 years old and free of cardiovascular disease) at baseline and after a mean of 9.4 years. Predictors of changes in DC and YEM for each sex were evaluated using multivariable linear regression models. The 1236 men (46.6%) were 60.0 (SD, 9.3) years: 40% were white, 22% black, 16% Chinese, and 22% Hispanic. The 1414 (53.4%) women were 59.8 (9.4) years old with a similar race distribution. Despite similar rates of change in DC and YEM, predictors of changes in distensibility markers differed by sex. In men, Chinese ( P =0.002) and black ( P =0.003) race/ethnicity, systolic blood pressure ( P =0.012), and diabetes mellitus ( P =0.05) were associated with more rapidly decreasing DC (accelerated stiffening). Starting antihypertensive medication was associated with improved DC ( P =0.03); stopping antihypertensives was associated with more rapid stiffening (increased YEM, P =0.05). In women, higher education was associated with slower stiffening (DC, P =0.041; YEM, P <0.001) as was use of lipid-lowering medication ( P =0.03), whereas baseline use of antihypertensive medications (YEM, P =0.01) and systolic blood pressure (DC, P =0.02; P =0.04) predicted increasing stiffening in women. Conclusions—: Longitudinal changes in carotid artery stiffness are associated with systolic blood pressure and antihypertensive therapy in both sexes; however, race/ethnicity (in men) and level of education (in women) may have different contributions between the sexes. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304990/pdf https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.114.304870 |
| Ending Page | 484 |
| Page Count | 7 |
| Starting Page | 478 |
| ISSN | 10795642 |
| e-ISSN | 15244636 |
| DOI | 10.1161/atvbaha.114.304870 |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Issue Number | 2 |
| Volume Number | 35 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2015-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Arteriosclerosis, thrombosis, and vascular biology Peripheral Vascular Disease Carotid Arteries Cardiovascular Diseases Vascular Stiffness Sex Characteristics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
