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Thrombocytopenia and Platelet Abnormalities in High-Density Lipoprotein Receptor–Deficient Mice
| Content Provider | Scilit |
|---|---|
| Author | Dole, Vandana S. Matuskova, Jana Vasile, Eliza Yesilaltay, Ayce Bergmeier, Wolfgang Bernimoulin, Michael Wagner, Denisa D. Krieger, Monty |
| Copyright Year | 2008 |
| Description | Journal: Arteriosclerosis, thrombosis, and vascular biology Objective— High-density lipoprotein (HDL) receptor, scavenger receptor class B, type I (SR-BI), mediated cellular uptake of lipoprotein cholesterol controls HDL structure and plasma HDL and biliary cholesterol levels. In SR-BI knockout (KO) mice, an unusually high plasma unesterified-to-total cholesterol ratio (UC:TC) and abnormally large HDL particles apparently contribute to pathology, including female infertility, susceptibility to atherosclerosis and coronary heart disease, and anemia. Here we examined the influence of SR-BI deficiency on platelets. Methods and Results— The high plasma UC:TC ratio in SR-BI KO mice was correlated with platelet abnormalities, including high cholesterol content, abnormal morphologies, high clearance rates, and thrombocytopenia. One day after platelets from wild-type mice were infused into SR-BI KO mice, they exhibited abnormally high cholesterol content and clearance rates similar to those of endogenous platelets. Platelets from SR-BI KO mice exhibited in vitro a blunted aggregation response to the agonist ADP but a normal response to PAR4. Conclusions— In SR-BI KO mice abnormal circulating lipoproteins, particularly their high UC:TC ratio—rather than the absence of SR-BI in platelets themselves—induce defects in platelet structure and clearance, together with a mild defect in function. |
| Related Links | http://atvb.ahajournals.org/content/atvbaha/28/6/1111.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683374/pdf https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.108.162347 |
| Ending Page | 1116 |
| Page Count | 6 |
| Starting Page | 1111 |
| ISSN | 10795642 |
| e-ISSN | 15244636 |
| DOI | 10.1161/atvbaha.108.162347 |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Issue Number | 6 |
| Volume Number | 28 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2008-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Arteriosclerosis, thrombosis, and vascular biology Endocrinology and Metabolism |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
