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Intrahepatic Recurrence After Resection of Hepatocellular Carcinoma Complicating Cirrhosis
| Content Provider | Scilit |
|---|---|
| Author | Belghiti, Jacques Panis, Yves Faroes, Olivier Benhamou, Jean Pierre Fekete, Francois |
| Copyright Year | 1991 |
| Description | Journal: Annals of Surgery To determine whether a careful evaluation of tumor extension by preoperative computed tomography scan after intra-arterial injection of ultrafluid lipiodol and by intraoperative ultrasound examination reduced the recurrence rate of hepatocellular carcinoma after resection, a series of 47 cirrhotic patients with a single tumor operated on from 1984 was studied. Alphafetoprotein level was less than 100 ng/mL in 26 patients (55%), size of the tumor was less than 5 cm in 28 patients (59%), and capsule was present in 30 patients (63%). The resection was performed with free margin measuring 1 cm or more. The overall cumulative survival rates at 3 and 5 years were 35% and 17%, respectively. Intrahepatic recurrence was observed in 28 patients (60%), located less than 2 cm from the resection margin in only four patients. The cumulative intrahepatic recurrence rate at 3 years was 81% and was significantly higher in patients with tumor 5≥ 5 cm and in patients with preoperative alphafetoprotein level of 5≥ 100 ng/mL. In this series the cumulative intrahepatic recurrence rate at 5 years was 100%. This high recurrence rate after resection, even with careful evaluation of tumor extension, indicates that liver transplantation might be envisaged for the treatment of cirrhotic patients with resectable hepatocellular carcinoma. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1358509/pdf |
| Ending Page | 117 |
| Page Count | 4 |
| Starting Page | 114 |
| ISSN | 00034932 |
| e-ISSN | 15281140 |
| DOI | 10.1097/00000658-199108000-00004 |
| Journal | Annals of Surgery |
| Issue Number | 2 |
| Volume Number | 214 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 1991-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Annals of Surgery Liver Transplantation Hepatocellular Carcinoma Intrahepatic Recurrence |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery |
