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Carotid Intima-Media Thickness, Electrocardiographic Left Ventricular Hypertrophy, and Incidence of Intracerebral Hemorrhage
| Content Provider | Scilit |
|---|---|
| Author | Folsom, Aaron R. Yatsuya, Hiroshi Psaty, Bruce M. Shahar, Eyal Longstreth Jr, W. T. |
| Copyright Year | 2011 |
| Description | Journal: Stroke Background and Purpose—: Carotid intima-media thickness and electrocardiographic left ventricular hypertrophy are 2 subclinical cardiovascular disease measures associated with increased risk of total and ischemic strokes. Increased intima-media thickness and electrocardiographic left ventricular hypertrophy also may reflect end-organ hypertensive effects. Information is scant on the associations of these subclinical measures with intracerebral hemorrhage (ICH). We hypothesized that greater carotid intima-media thickness and the presence of electrocardiographic left ventricular hypertrophy would be independently associated with increased ICH incidence. Methods—: Among 18 155 participants initially free of stroke in the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS), we assessed carotid intima-media thickness, carotid plaque, and electrocardiographic left ventricular hypertrophy. Over a median of 18 years of follow-up, 162 incident ICH events occurred. Results—: After adjustment for other ICH risk factors, carotid intima-media thickness was associated positively with incidence of ICH in both ARIC and CHS. The risk was lowest in study-specific Quartile 1, elevated 1.6- to 2.6-fold in Quartiles 2 to 3, and elevated 2.5 to 3.7-fold in Quartile 4 ( P <0.05 for both studies). In CHS, having a carotid plaque was associated with a 2-fold (95% CI, 1.1–3.4) greater ICH risk than having no plaque, but only 1.2-fold (95% CI, 0.76–2.0) greater ICH risk in ARIC. Electrocardiographic left ventricular hypertrophy carried a hazard ratio of ICH of 1.7 (95% CI, 0.77–3.7) in CHS and 2.8 (95% CI, 1.2–6.4) in ARIC. Conclusions—: Our data suggest that people with carotid atherosclerosis and possibly left ventricular hypertrophy are at increased risk not only of ischemic stroke, but also of ICH. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202073/pdf https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.111.623157 |
| Ending Page | 3079 |
| Page Count | 5 |
| Starting Page | 3075 |
| ISSN | 00392499 |
| e-ISSN | 15244628 |
| DOI | 10.1161/strokeaha.111.623157 |
| Journal | Stroke |
| Issue Number | 11 |
| Volume Number | 42 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-11-01 |
| Access Restriction | Open |
| Subject Keyword | Peripheral Vascular Disease Left Ventricular Hypertrophy Intracerebral Hemorrhage Prospective Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical) |
