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Acetaminophen Pharmacokinetics in Children With Nonalcoholic Fatty Liver Disease
| Content Provider | Scilit |
|---|---|
| Author | Barshop, Nicole J. Capparelli, Edmund V. Sirlin, Claude B. Schwimmer, Jeffrey B. Lavine, Joel E. |
| Copyright Year | 2011 |
| Description | Journal: Journal of pediatric gastroenterology and nutrition Objectives: The aim of the study was to evaluate UDP-glucuronyltransferase activity and the pharmacokinetics of a single oral dose of acetaminophen (APAP) in children with nonalcoholic fatty liver disease (NAFLD). Patients and Methods: Twelve boys 10 to 17 years old with biopsy-proven NAFLD and 12 age- and sex-matched controls without NAFLD were recruited. Following administration of a single oral dose of APAP (5 mg/kg, maximum 325 mg), APAP and its glucuronide metabolite (APAP-G) were measured in plasma, urine, and sputum at various intervals up to 24 hours. The activity of UDP-glucuronyltransferase was estimated by the plasma ratio of APAP-G to APAP at 4 hours. Results: Following administration of APAP, children with NAFLD had significantly higher concentrations of APAP-G in serum (P = 0.0071) and urine (P = 0.0210) compared with controls. No significant differences in APAP pharmacokinetics parameters were observed between the 2 groups. Conclusions: APAP glucuronidation is altered in children with fatty liver disease. Despite the altered disposition of this metabolite, the pharmacokinetics of a single 5 mg/kg dose of APAP is the same in children with NAFLD as in children with normal liver function. |
| Related Links | http://europepmc.org/articles/pmc3059772?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059772/pdf |
| Ending Page | 202 |
| Page Count | 5 |
| Starting Page | 198 |
| ISSN | 02772116 |
| e-ISSN | 15364801 |
| DOI | 10.1097/mpg.0b013e3181f9b3a0 |
| Journal | Journal of pediatric gastroenterology and nutrition |
| Issue Number | 2 |
| Volume Number | 52 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of pediatric gastroenterology and nutrition Pediatrics and Child Health Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Udp-glucuronyltransferase |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology Pediatrics, Perinatology and Child Health |
