NDLI: Detachment of ligands from nanoparticle surface under flow and endothelial cell contact: Assessment using microfluidic devices

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Detachment of ligands from nanoparticle surface under flow and endothelial cell contact: Assessment using microfluidic devices

Content Provider	Scilit
Author	Jarvis, Maria Arnold, Michael Ott, Jenna Krishnan, Vinu Pant, Kapil Prabhakarpandian, Balabhaskar Mitragotri, Samir
Copyright Year	2018
Description	Journal: Bioengineering & Translational Medicine Surface modification of nanoparticles is a well‐established methodology to alter their properties to enhance circulation half‐life. While literature studies using conventional, in vitro characterization are routinely used to evaluate the biocompatibility of such modifications, relatively little attention has been paid to assess the stability of such surface modifications in physiologically relevant conditions. Here, microfluidic devices were used to study the effect of factors that adversely impact surface modifications including vascular flow and endothelial cell interactions. Camptothecin nanoparticles coated with polyethylene glycol (PEG) and/or folic acid were analyzed using linear channels and microvascular networks. Detachment of PEG was observed in cell‐free conditions and was attributed to interplay between the flow and method of PEG attachment. The flow and cells also impacted the surface charge of nanoparticles. Presence of endothelial cells further increased PEG shedding. The results demonstrate that endothelial cell contact, and vascular flow parameters modify surface ligands on nanoparticle surfaces.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063868/pdf
Ending Page	155
Page Count	8
Starting Page	148
ISSN	23806761
e-ISSN	23806761
DOI	10.1002/btm2.10089
Journal	Bioengineering & Translational Medicine
Issue Number	2
Volume Number	3
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2018-04-17
Access Restriction	Open
Subject Keyword	Journal: Bioengineering & Translational Medicine Biotechnology and Microbiology Microfluidic Device
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Biotechnology Pharmaceutical Science

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