NDLI: Occupational exposures and longitudinal lung function decline

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Occupational exposures and longitudinal lung function decline

Content Provider	Scilit
Author	Liao, Shu-Yi Lin, Xihong Christiani, David C.
Copyright Year	2014
Description	Journal: American journal of industrial medicine Few longitudinal studies have been conducted on occupational exposure and lung function. This study investigated occupational dust exposure effects on lung function and whether genetic variants influence such effects. The study population (1,332 participants) was from the Framingham Heart Study, in which participant lung function measures were available from up to five examinations over nearly 17 years. Occupational dust exposures were classified into "more" and "less" likely dust exposure. We used linear mixed effects models for the analysis. Participants with more likely dust exposure had a mean 4.5 mL/year excess loss rate of FEV1 over time. However, occupational dust exposures alone or interactions with age or time had no significant effect on FEV1 /FVC. No statistically significant effects of genetic modifications in the different subgroups were identified for FEV1 loss. Occupational dust exposures may accelerate the rate of FEV1 loss but not FEV1 /FVC loss.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512740/pdf
Ending Page	20
Page Count	7
Starting Page	14
e-ISSN	10970274
DOI	10.1002/ajim.22389
Journal	American journal of industrial medicine
Issue Number	1
Volume Number	58
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-11-10
Access Restriction	Open
Subject Keyword	Journal: American journal of industrial medicine Public, Environmental and Occupational Health Chronic Obstructive Pulmonary Disease Environmental Health Environmental Lung Disease Forced Expiratory Volume in One Second Job Exposure Matrix Occupational Health Occupational Respiratory Disease
Content Type	Text
Resource Type	Article

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